C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: chemokine (C-C motif) receptor 7
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000037944 Ccr7 10090 - 11:99144196-99155077 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000103134 Ccr7-001 99144196-99155077 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000103134
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000103134 1.090±0.14 0.329±0.10 0.489±0.12 0.020±0.00 56.518±25.15 1.935±0.40 0.914±0.19 2.451±1.98 0.388±0.25 7.222±1.62 0.457±0.76 0.690±0.30 0.150±0.09 0.749±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005QX CIL_0005QX_0002 CGP 11:99065678-99155077
CIL_0005QY CIL_0005QY_0002 CGP 11:99144196-99231017

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001768 TAS establishment of T cell polarity
GO:0002408 IEA myeloid dendritic cell chemotaxis
GO:0002518 TAS lymphocyte chemotaxis across high endothelial venule
GO:0002606 IDA positive regulation of dendritic cell antigen processing and presentation
GO:0002649 TAS regulation of tolerance induction to self antigen
GO:0002885 IMP positive regulation of hypersensitivity
GO:0002922 IMP positive regulation of humoral immune response
GO:0004930 TAS G-protein coupled receptor activity
GO:0005515 IPI protein binding
GO:0005622 IDA intracellular
GO:0005886 IDA plasma membrane
GO:0006935 IMP chemotaxis
GO:0006954 TAS inflammatory response
GO:0006955 IMP immune response
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0007257 IC activation of JUN kinase activity
GO:0009897 IDA external side of plasma membrane
GO:0009986 IDA cell surface
GO:0010759 NAS positive regulation of macrophage chemotaxis
GO:0010820 TAS positive regulation of T cell chemotaxis
GO:0016021 IEA integral component of membrane
GO:0016493 IMP C-C chemokine receptor activity
GO:0030036 TAS actin cytoskeleton organization
GO:0032320 IC positive regulation of Ras GTPase activity
GO:0032496 IDA response to lipopolysaccharide
GO:0032649 IMP regulation of interferon-gamma production
GO:0032735 IMP positive regulation of interleukin-12 production
GO:0032760 IC positive regulation of tumor necrosis factor production
GO:0034695 TAS response to prostaglandin E
GO:0035757 ISS chemokine (C-C motif) ligand 19 binding
GO:0035758 ISS chemokine (C-C motif) ligand 21 binding
GO:0038115 IEA chemokine (C-C motif) ligand 19 signaling pathway
GO:0038116 IEA chemokine (C-C motif) ligand 21 signaling pathway
GO:0038117 IEA C-C motif chemokine 19 receptor activity
GO:0038121 IEA C-C motif chemokine 21 receptor activity
GO:0042102 IC positive regulation of T cell proliferation
GO:0043089 IC positive regulation of Cdc42 GTPase activity
GO:0045060 IMP negative thymic T cell selection
GO:0045627 IC positive regulation of T-helper 1 cell differentiation
GO:0048260 IC positive regulation of receptor-mediated endocytosis
GO:0048535 TAS lymph node development
GO:0050706 IMP regulation of interleukin-1 beta secretion
GO:0050718 IC positive regulation of interleukin-1 beta secretion
GO:0050766 NAS positive regulation of phagocytosis
GO:0050862 IMP positive regulation of T cell receptor signaling pathway
GO:0051491 TAS positive regulation of filopodium assembly
GO:0071345 IEA cellular response to cytokine stimulus
GO:0071731 TAS response to nitric oxide
GO:0072610 IMP interleukin-12 secretion
GO:0090023 IMP positive regulation of neutrophil chemotaxis
GO:0097022 TAS lymphocyte migration into lymph node
GO:0097029 IMP mature dendritic cell differentiation
GO:2000107 TAS negative regulation of leukocyte apoptotic process
GO:2000147 TAS positive regulation of cell motility
GO:2000412 TAS positive regulation of thymocyte migration
GO:2000510 IMP positive regulation of dendritic cell chemotaxis
GO:2000522 IMP positive regulation of immunological synapse formation
GO:2000525 IMP positive regulation of T cell costimulation
GO:2000526 IMP positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation
GO:2000547 IC regulation of dendritic cell dendrite assembly

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000044561 ccr7 chemokine (C-C motif) receptor 7 protein_coding Danio_rerio
ENSG00000126353 CCR7 chemokine (C-C motif) receptor 7 protein_coding Homo_sapiens

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