C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: FYVE, RhoGEF and PH domain containing 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000127084 FGD3 9606 + 9:92947451-93036236 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000337352 FGD3-201 92974482-93036232 protein_coding
  ENST00000375482 FGD3-001 92947451-93036236 protein_coding
  ENST00000416701 FGD3-202 92963961-93036236 protein_coding
  ENST00000467786 FGD3-002 92975250-93036236 nonsense_mediated_decay
  ENST00000468206 FGD3-006 92964106-92976709 processed_transcript
  ENST00000488407 FGD3-003 93029874-93034619 processed_transcript
  ENST00000494553 FGD3-004 93015651-93018200 processed_transcript
  ENST00000494669 FGD3-005 92974500-92976707 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000337352ENST00000375482ENST00000416701ENST00000467786ENST00000468206ENST00000488407
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000337352 N/A N/A 0.290±0.00 N/A N/A N/A 0.044±0.00 N/A N/A 1.084±0.00 0.172±0.00 N/A 1.215±0.00 N/A
ENST00000375482 0.877±0.00 5.240±0.00 N/A 0.380±0.00 0.740±0.00 0.285±0.14 0.334±0.00 1.629±0.00 0.503±0.00 2.743±0.00 0.111±0.00 2.132±0.86 2.071±1.25 4.828±0.61
ENST00000416701 0.327±0.00 N/A N/A N/A 0.670±0.00 N/A 0.039±0.00 N/A N/A 1.674±0.14 N/A 0.463±0.02 0.782±0.18 N/A
ENST00000467786 0.123±0.00 3.013±0.00 0.110±0.00 0.153±0.00 0.258±0.00 0.068±0.00 0.092±0.03 0.607±0.22 0.061±0.00 0.868±0.00 N/A 1.539±0.00 N/A N/A
ENST00000468206 N/A N/A N/A N/A N/A 1.650±0.00 N/A N/A 0.859±0.00 N/A 0.099±0.00 1.025±0.00 N/A N/A
ENST00000488407 N/A N/A N/A N/A N/A 0.618±0.00 N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001726 ISS ruffle
GO:0005085 ISS guanyl-nucleotide exchange factor activity
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005737 ISS cytoplasm
GO:0005794 ISS Golgi apparatus
GO:0005829 TAS cytosol
GO:0005856 IEA cytoskeleton
GO:0007010 ISS cytoskeleton organization
GO:0007264 TAS small GTPase mediated signal transduction
GO:0008360 ISS regulation of cell shape
GO:0030027 ISS lamellipodium
GO:0030036 ISS actin cytoskeleton organization
GO:0031267 ISS small GTPase binding
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0043065 TAS positive regulation of apoptotic process
GO:0043088 ISS regulation of Cdc42 GTPase activity
GO:0043547 ISS positive regulation of GTPase activity
GO:0046847 ISS filopodium assembly
GO:0046872 IEA metal ion binding
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051056 TAS regulation of small GTPase mediated signal transduction
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000037946 Fgd3 FYVE, RhoGEF and PH domain containing 3 protein_coding Mus_musculus

Loading