C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: FYVE, RhoGEF and PH domain containing 3
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000375482 FGD3-001 ENSG00000127084 9606 + 9:92947451-93036236 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000375482
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000375482 0.877±0.00 5.240±0.00 0.380±0.00 0.740±0.00 0.285±0.14 0.334±0.00 1.629±0.00 0.503±0.00 2.743±0.00 0.111±0.00 2.132±0.86 2.071±1.25 4.828±0.61

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001726 ISS ruffle
GO:0005085 ISS guanyl-nucleotide exchange factor activity
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005737 ISS cytoplasm
GO:0005794 ISS Golgi apparatus
GO:0005829 TAS cytosol
GO:0005856 IEA cytoskeleton
GO:0007010 ISS cytoskeleton organization
GO:0007264 TAS small GTPase mediated signal transduction
GO:0008360 ISS regulation of cell shape
GO:0030027 ISS lamellipodium
GO:0030036 ISS actin cytoskeleton organization
GO:0031267 ISS small GTPase binding
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0043065 TAS positive regulation of apoptotic process
GO:0043088 ISS regulation of Cdc42 GTPase activity
GO:0043547 ISS positive regulation of GTPase activity
GO:0046847 ISS filopodium assembly
GO:0046872 IEA metal ion binding
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051056 TAS regulation of small GTPase mediated signal transduction
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000048716 Fgd3-002 protein_coding Mus_musculus 0 1411
ENSMUST00000110087 Fgd3-001 protein_coding Mus_musculus 0 1411
ENSMUST00000110086 Fgd3-003 protein_coding Mus_musculus 0 1230
ENSMUST00000026296 Fgd1-001 protein_coding Mus_musculus 0 381
ENSMUST00000112685 Fgd1-002 protein_coding Mus_musculus 0 381
ENSDART00000127344 fgd-201 protein_coding Danio_rerio 0.000000002 69

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