C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: HECT and RLD domain containing E3 ubiquitin protein ligase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000128731 HERC2 9606 - 15:28111040-28322152 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000261609 HERC2-001 28111040-28322152 protein_coding
  ENST00000562136 HERC2-008 28111762-28113717 retained_intron
  ENST00000563670 HERC2-007 28272044-28273168 retained_intron
  ENST00000563945 HERC2-002 28320122-28322119 processed_transcript
  ENST00000564383 HERC2-009 28280034-28299483 retained_intron
  ENST00000564519 HERC2-012 28141739-28142452 retained_intron
  ENST00000564734 HERC2-003 28254488-28322149 nonsense_mediated_decay
  ENST00000566635 HERC2-006 28111279-28117551 retained_intron
  ENST00000567869 HERC2-004 28190201-28203936 retained_intron
  ENST00000568206 HERC2-005 28115281-28118421 retained_intron
  ENST00000569335 HERC2-010 28222148-28229516 retained_intron
  ENST00000569772 HERC2-011 28152759-28174423 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000261609ENST00000566635
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000261609 1.266±0.00 1.360±0.00 3.283±0.00 2.256±0.14 2.079±1.04 1.149±0.10 2.905±1.61 0.932±0.03 1.765±1.39 1.529±1.06 1.518±0.00 2.143±1.12 0.827±0.21 2.095±1.02
ENST00000566635 N/A N/A N/A 7.006±0.00 N/A 4.940±0.00 N/A 5.609±0.00 1.792±0.00 3.200±0.00 7.765±0.00 16.970±4.25 5.079±2.03 9.400±4.39

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004842 IDA:IEA ubiquitin-protein transferase activity
GO:0005085 NAS guanyl-nucleotide exchange factor activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005743 IEA mitochondrial inner membrane
GO:0005856 IEA cytoskeleton
GO:0006281 IDA DNA repair
GO:0006886 NAS intracellular protein transport
GO:0006974 IDA cellular response to DNA damage stimulus
GO:0007283 IEA spermatogenesis
GO:0008270 IEA zinc ion binding
GO:0016020 IDA membrane
GO:0016567 IDA:IEA protein ubiquitination
GO:0016874 IEA ligase activity
GO:0020037 IEA heme binding
GO:0031625 IPI ubiquitin protein ligase binding
GO:0032183 IDA SUMO binding
GO:0042787 IBA protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043547 NAS positive regulation of GTPase activity
GO:0046872 IEA metal ion binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000073841 herc2 hect domain and RLD 2 protein_coding Danio_rerio
ENSMUSG00000030451 Herc2 hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 2 protein_coding Mus_musculus

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