C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000030451 Herc2 10090 + 7:56050155-56231794 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000076226 Herc2-201 56050155-56231794 protein_coding
  ENSMUST00000164095 Herc2-202 56050389-56231763 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000076226ENSMUST00000164095
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000076226 2.598±1.13 2.138±0.96 6.296±1.16 6.309±1.80 2.337±1.04 1.481±0.65 1.937±0.29 2.190±0.71 1.600±1.00 4.339±1.15 4.461±1.23 4.502±1.98 3.921±1.50 4.401±1.52
ENSMUST00000164095 2.649±0.29 3.306±1.79 N/A 16.740±0.00 3.208±1.00 3.477±0.26 1.823±0.34 2.072±0.81 1.392±0.74 2.294±0.81 2.405±0.80 6.004±2.86 7.526±2.76 5.565±0.76

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000391 CIL_000391_0002 CGP 7:55977567-56231794
CIL_0006LG CIL_0006LG_0002 CGP 7:56050155-56536517

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004842 ISS ubiquitin-protein transferase activity
GO:0005634 ISS nucleus
GO:0005737 ISS cytoplasm
GO:0005743 IDA mitochondrial inner membrane
GO:0005856 IEA cytoskeleton
GO:0006281 ISS DNA repair
GO:0006974 ISS cellular response to DNA damage stimulus
GO:0007283 IMP spermatogenesis
GO:0008270 IEA zinc ion binding
GO:0016020 IEA membrane
GO:0016567 ISS protein ubiquitination
GO:0016874 IEA ligase activity
GO:0020037 IEA heme binding
GO:0031625 IEA ubiquitin protein ligase binding
GO:0032183 ISS SUMO binding
GO:0042787 IBA protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000073841 herc2 hect domain and RLD 2 protein_coding Danio_rerio
ENSG00000128731 HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 protein_coding Homo_sapiens

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