C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitogen-activated protein kinase kinase kinase 10
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000130758 MAP3K10 9606 + 19:40191744-40215575 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000253055 MAP3K10-001 40191744-40215575 protein_coding
  ENST00000593502 MAP3K10-004 40198424-40213261 nonsense_mediated_decay
  ENST00000593906 MAP3K10-005 40192245-40204616 processed_transcript
  ENST00000594569 MAP3K10-007 40205530-40206402 retained_intron
  ENST00000594791 MAP3K10-008 40209152-40213734 retained_intron
  ENST00000594951 MAP3K10-003 40198397-40209202 nonsense_mediated_decay
  ENST00000597986 MAP3K10-002 40198443-40215528 nonsense_mediated_decay
  ENST00000601702 MAP3K10-006 40204601-40206001 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000253055ENST00000593906ENST00000594569ENST00000594791ENST00000594951ENST00000597986
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000253055 5.912±0.00 2.391±0.00 14.241±10.13 6.448±0.00 2.449±2.42 6.279±0.00 0.764±0.00 0.500±0.00 5.343±0.00 1.574±0.84 3.371±2.34 3.850±1.21 5.702±0.34
ENST00000593906 N/A N/A N/A 0.302±0.00 N/A N/A N/A N/A 0.493±0.00 N/A N/A N/A N/A
ENST00000594569 N/A 3.268±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000594791 N/A 3.092±0.00 N/A N/A 0.307±0.00 N/A N/A 0.544±0.00 N/A N/A 3.415±0.00 N/A N/A
ENST00000594951 N/A 3.399±0.00 22.006±0.00 0.327±0.00 N/A N/A 4.219±0.00 N/A N/A N/A 3.798±0.00 2.618±0.00 10.498±5.65
ENST00000597986 N/A N/A N/A N/A N/A 0.084±0.00 0.040±0.00 0.554±0.00 0.134±0.00 N/A 2.075±0.00 N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 IEA MAPK cascade
GO:0000186 IEA activation of MAPKK activity
GO:0003714 ISS transcription corepressor activity
GO:0004672 TAS:IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004706 ISS JUN kinase kinase kinase activity
GO:0004709 IEA MAP kinase kinase kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IEA protein binding
GO:0005524 IEA ATP binding
GO:0005737 IDA cytoplasm
GO:0006468 IEA protein phosphorylation
GO:0006915 TAS apoptotic process
GO:0007165 TAS signal transduction
GO:0007224 IMP smoothened signaling pathway
GO:0007254 TAS JNK cascade
GO:0007256 ISS activation of JNKK activity
GO:0007257 ISS activation of JUN kinase activity
GO:0008219 IEA cell death
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0018107 IDA peptidyl-threonine phosphorylation
GO:0042803 ISS protein homodimerization activity
GO:0043065 IEA positive regulation of apoptotic process
GO:0043425 IPI bHLH transcription factor binding
GO:0043433 IMP negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043507 IMP positive regulation of JUN kinase activity
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0046330 IMP positive regulation of JNK cascade
GO:0046777 ISS protein autophosphorylation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000055672 map3k10 mitogen-activated protein kinase kinase kinase 10 protein_coding Danio_rerio
ENSMUSG00000040390 Map3k10 mitogen-activated protein kinase kinase kinase 10 protein_coding Mus_musculus

Loading