C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: mitogen-activated protein kinase kinase kinase 10
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000253055 MAP3K10-001 ENSG00000130758 9606 + 19:40191744-40215575 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000253055
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000253055 5.912±0.00 2.391±0.00 14.241±10.13 6.448±0.00 2.449±2.42 6.279±0.00 0.764±0.00 0.500±0.00 5.343±0.00 1.574±0.84 3.371±2.34 3.850±1.21 5.702±0.34

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0003714 ISS transcription corepressor activity
GO:0004672 TAS:IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004706 ISS JUN kinase kinase kinase activity
GO:0004709 IEA MAP kinase kinase kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IEA protein binding
GO:0005524 IEA ATP binding
GO:0005737 IDA cytoplasm
GO:0006468 IEA protein phosphorylation
GO:0006915 TAS apoptotic process
GO:0007165 TAS signal transduction
GO:0007224 IMP smoothened signaling pathway
GO:0007254 TAS JNK cascade
GO:0007256 ISS activation of JNKK activity
GO:0007257 ISS activation of JUN kinase activity
GO:0008219 IEA cell death
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0018107 IDA peptidyl-threonine phosphorylation
GO:0042803 ISS protein homodimerization activity
GO:0043065 IEA positive regulation of apoptotic process
GO:0043425 IPI bHLH transcription factor binding
GO:0043433 IMP negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043507 IMP positive regulation of JUN kinase activity
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0046330 IMP positive regulation of JNK cascade
GO:0046777 ISS protein autophosphorylation

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000036453 Map3k10-001 protein_coding Mus_musculus 0 3624
ENSMUST00000108341 Map3k10-201 protein_coding Mus_musculus 0 3334
ENSMUST00000138243 Map3k10-002 retained_intron Mus_musculus 0 1325
ENSMUST00000152032 Map3k10-003 retained_intron Mus_musculus 0 475
ENSMUST00000133551 Map3k10-004 retained_intron Mus_musculus 0 272

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