C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ATP citrate lyase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000131473 ACLY 9606 - 17:41866908-41930542 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000352035 ACLY-001 41866908-41918987 protein_coding
  ENST00000353196 ACLY-201 41866931-41919019 protein_coding
  ENST00000393896 ACLY-002 41867574-41919022 protein_coding
  ENST00000537919 ACLY-004 41867456-41918983 protein_coding
  ENST00000588547 ACLY-008 41904440-41905641 retained_intron
  ENST00000588779 ACLY-009 41867761-41870719 processed_transcript
  ENST00000590151 ACLY-003 41866917-41918962 protein_coding
  ENST00000590735 ACLY-007 41906598-41918951 processed_transcript
  ENST00000590770 ACLY-006 41897801-41918951 protein_coding
  ENST00000592970 ACLY-005 41910239-41930542 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000352035ENST00000353196ENST00000393896ENST00000537919ENST00000590151ENST00000590770
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000352035 11.077±0.00 4.268±0.00 2.976±0.00 8.960±3.26 13.270±8.44 4.905±1.32 1.811±0.19 N/A 8.015±0.00 5.128±0.55 2.189±0.00 14.487±5.20 11.358±4.18 10.713±5.04
ENST00000353196 8.162±0.00 4.944±0.00 1.676±0.00 N/A N/A 3.208±0.00 3.715±0.00 7.801±0.00 1.964±0.00 2.912±1.30 8.360±0.00 9.713±0.00 9.104±2.29 N/A
ENST00000393896 9.777±0.00 N/A N/A 9.561±0.00 9.324±8.01 5.895±0.00 N/A N/A N/A 7.529±0.00 N/A 11.109±6.55 7.711±2.45 6.950±2.56
ENST00000537919 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 26.961±0.00 9.576±0.00 14.764±0.00
ENST00000590151 N/A 7.913±0.00 N/A 3.330±0.00 3.002±0.00 3.268±0.14 1.375±0.68 6.192±4.01 5.796±0.36 3.404±2.29 N/A 8.374±0.00 8.828±0.00 3.488±0.00
ENST00000590770 N/A N/A 13.561±0.00 13.029±0.00 12.903±0.00 22.862±0.00 3.107±0.00 20.698±0.00 32.293±0.00 9.661±0.00 N/A 45.417±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000KS CIL_0000KS_0002 CGP 17:41853545-41930542
CIL_0006EG CIL_0006EG_0001 CGP 17:41866908-41965651

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003824 IEA catalytic activity
GO:0003878 TAS:IEA ATP citrate synthase activity
GO:0004775 IEA succinate-CoA ligase (ADP-forming) activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA:IEA cytoplasm
GO:0005739 IEA mitochondrion
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0006101 TAS citrate metabolic process
GO:0006112 TAS energy reserve metabolic process
GO:0006200 TAS ATP catabolic process
GO:0008152 IEA metabolic process
GO:0008610 IDA lipid biosynthetic process
GO:0009346 TAS citrate lyase complex
GO:0015936 TAS coenzyme A metabolic process
GO:0016020 IDA membrane
GO:0019432 TAS triglyceride biosynthetic process
GO:0031325 TAS positive regulation of cellular metabolic process
GO:0035338 TAS long-chain fatty-acyl-CoA biosynthetic process
GO:0044255 TAS cellular lipid metabolic process
GO:0044262 IEA cellular carbohydrate metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0046872 IEA metal ion binding
GO:0046912 IEA transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
GO:0048037 IEA cofactor binding
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000017738 aclya ATP citrate lyase a protein_coding Danio_rerio
ENSDARG00000055652 aclyb ATP citrate lyase b protein_coding Danio_rerio
ENSMUSG00000020917 Acly ATP citrate lyase protein_coding Mus_musculus

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