C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: dopa decarboxylase (aromatic L-amino acid decarboxylase)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000132437 DDC 9606 - 7:50458436-50565457 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000357936 DDC-001 50458436-50561054 protein_coding
  ENST00000380984 DDC-014 50492647-50561048 protein_coding
  ENST00000420203 DDC-003 50543994-50564334 protein_coding
  ENST00000426377 DDC-013 50458440-50561054 protein_coding
  ENST00000430300 DDC-006 50458477-50543982 protein_coding
  ENST00000431062 DDC-009 50458440-50544119 protein_coding
  ENST00000444124 DDC-002 50458465-50565457 protein_coding
  ENST00000444733 DDC-008 50458440-50561054 nonsense_mediated_decay
  ENST00000489162 DDC-012 50527692-50540028 processed_transcript
  ENST00000494914 DDC-010 50458570-50479963 retained_intron
  ENST00000495320 DDC-011 50458442-50459684 processed_transcript
  ENST00000615193 DDC-201 50458438-50561071 protein_coding
  ENST00000617822 DDC-202 50458438-50561071 protein_coding
  ENST00000622873 DDC-203 50458438-50561071 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderColonKidneyLiverLungOvaryENST00000357936ENST00000426377ENST00000430300ENST00000444124ENST00000494914ENST00000622873
Transcript ID Bladder Colon Kidney Liver Lung Ovary
ENST00000357936 N/A 1.324±0.00 14.089±0.00 N/A N/A N/A
ENST00000426377 N/A 0.982±0.00 5.234±0.00 3.590±0.00 N/A N/A
ENST00000430300 17.157±0.00 N/A N/A N/A N/A N/A
ENST00000444124 15.762±0.00 5.936±0.00 3.331±0.00 2.707±0.00 N/A 6.393±3.06
ENST00000494914 N/A N/A 9.974±0.00 2.197±0.00 0.289±0.00 N/A
ENST00000622873 5.821±0.00 N/A 6.870±0.00 N/A N/A 6.925±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008XP CIL_0008XP_0001 VISTA 7:49879868-50480692
CIL_0008P3 CIL_0008P3_0001 VISTA 7:49993452-50594868
CIL_0008XT CIL_0008XT_0001 VISTA 7:50018042-50619048
CIL_0007SD CIL_0007SD_0001 VISTA 7:50081734-50682493
CIL_00089U CIL_00089U_0001 VISTA 7:50196544-50798008
CIL_000642 CIL_000642_0001 CGP 7:50304124-50542535
CIL_0008KL CIL_0008KL_0001 VISTA 7:50358274-50958701
CIL_000641 CIL_000641_0001 CGP 7:50444128-50565457
CIL_0004WV CIL_0004WV_0002 CGP 7:50458436-50793462

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004058 IDA aromatic-L-amino-acid decarboxylase activity
GO:0005515 IPI protein binding
GO:0005737 IEA cytoplasm
GO:0005829 TAS cytosol
GO:0006520 IEA cellular amino acid metabolic process
GO:0007623 IEA circadian rhythm
GO:0008021 IEA synaptic vesicle
GO:0009636 IEA response to toxic substance
GO:0010259 IEA multicellular organismal aging
GO:0015842 IEA synaptic vesicle amine transport
GO:0016597 IEA amino acid binding
GO:0016829 IEA lyase activity
GO:0016831 IEA carboxy-lyase activity
GO:0019752 IEA carboxylic acid metabolic process
GO:0019899 IPI enzyme binding
GO:0019904 IEA protein domain specific binding
GO:0030170 IEA pyridoxal phosphate binding
GO:0030424 IEA axon
GO:0033076 IEA isoquinoline alkaloid metabolic process
GO:0034641 TAS cellular nitrogen compound metabolic process
GO:0035690 IEA cellular response to drug
GO:0036468 IDA L-dopa decarboxylase activity
GO:0042416 IEA dopamine biosynthetic process
GO:0042423 TAS catecholamine biosynthetic process
GO:0042427 IEA serotonin biosynthetic process
GO:0043025 IEA neuronal cell body
GO:0044281 TAS small molecule metabolic process
GO:0046219 TAS indolalkylamine biosynthetic process
GO:0046684 IEA response to pyrethroid
GO:0052314 IEA phytoalexin metabolic process
GO:0070062 IDA extracellular vesicular exosome
GO:0071312 IEA cellular response to alkaloid
GO:0071363 IEA cellular response to growth factor stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000016494 ddc dopa decarboxylase protein_coding Danio_rerio
ENSMUSG00000020182 Ddc dopa decarboxylase protein_coding Mus_musculus

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