C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: dopa decarboxylase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000020182 Ddc 10090 - 11:11814101-11898144 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000066237 Ddc-001 11814101-11898044 protein_coding
  ENSMUST00000109659 Ddc-201 11814103-11890408 protein_coding
  ENSMUST00000122971 Ddc-004 11844977-11864907 processed_transcript
  ENSMUST00000134121 Ddc-005 11875276-11890398 processed_transcript
  ENSMUST00000134401 Ddc-003 11819351-11836280 processed_transcript
  ENSMUST00000136810 Ddc-007 11814103-11822921 processed_transcript
  ENSMUST00000145033 Ddc-006 11873337-11880629 processed_transcript
  ENSMUST00000146359 Ddc-008 11861841-11890401 processed_transcript
  ENSMUST00000155690 Ddc-002 11846658-11890369 protein_coding
  ENSMUST00000178704 Ddc-202 11814101-11898144 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000066237ENSMUST00000109659ENSMUST00000134121ENSMUST00000134401ENSMUST00000136810ENSMUST00000145033ENSMUST00000146359ENSMUST00000155690ENSMUST00000178704
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000066237 0.127±0.04 N/A N/A N/A 0.128±0.06 N/A N/A N/A N/A 1.068±0.22 0.116±0.05 0.200±0.12 0.322±0.15 0.089±0.02
ENSMUST00000109659 N/A 6.069±0.81 1.639±0.00 4.372±0.75 N/A 4.040±2.01 1.028±0.16 N/A N/A 1.519±0.65 N/A N/A N/A N/A
ENSMUST00000134121 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.218±0.00 N/A 0.049±0.00
ENSMUST00000134401 N/A N/A N/A N/A 0.373±0.00 N/A N/A N/A N/A N/A 0.166±0.06 0.155±0.00 N/A 0.251±0.00
ENSMUST00000136810 0.063±0.00 N/A N/A N/A 0.117±0.00 N/A N/A N/A N/A N/A 0.127±0.08 0.218±0.12 1.271±0.61 0.121±0.00
ENSMUST00000145033 N/A N/A N/A N/A 0.185±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 0.053±0.00
ENSMUST00000146359 N/A N/A N/A N/A 0.069±0.04 N/A 0.247±0.04 N/A N/A N/A N/A 0.093±0.00 N/A 0.030±0.00
ENSMUST00000155690 0.080±0.00 3.994±0.57 0.672±0.00 2.470±0.00 0.362±0.00 9.481±2.16 N/A N/A 13.017±0.00 N/A N/A 0.229±0.07 N/A N/A
ENSMUST00000178704 0.037±0.00 N/A N/A N/A 0.471±0.00 11.443±2.34 N/A 53.272±1.23 23.064±18.22 0.370±0.19 N/A 0.143±0.00 5.614±5.95 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008XP CIL_0008XP_0002 VISTA 11:11227967-11828770
CIL_0008P3 CIL_0008P3_0002 VISTA 11:11375621-11977027
CIL_0008XT CIL_0008XT_0002 VISTA 11:11399170-12000205
CIL_0007SD CIL_0007SD_0002 VISTA 11:11453227-12053958
CIL_00089U CIL_00089U_0002 VISTA 11:11536402-12137998
CIL_0008KL CIL_0008KL_0002 VISTA 11:11661856-12262621
CIL_000641 CIL_000641_0002 CGP 11:11787431-11898144
CIL_0004WV CIL_0004WV_0003 CGP 11:11814101-12038683

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004058 IDA aromatic-L-amino-acid decarboxylase activity
GO:0005515 IEA protein binding
GO:0005737 IDA cytoplasm
GO:0006520 IEA cellular amino acid metabolic process
GO:0007623 IEA circadian rhythm
GO:0008021 IEA synaptic vesicle
GO:0009636 IDA response to toxic substance
GO:0010259 IEA multicellular organismal aging
GO:0015842 IEA synaptic vesicle amine transport
GO:0016597 IEA amino acid binding
GO:0019899 IEA enzyme binding
GO:0019904 IEA protein domain specific binding
GO:0030170 IEA pyridoxal phosphate binding
GO:0030424 IEA axon
GO:0033076 IEA isoquinoline alkaloid metabolic process
GO:0035690 IEA cellular response to drug
GO:0036468 IEA L-dopa decarboxylase activity
GO:0042416 IEA dopamine biosynthetic process
GO:0042427 IEA serotonin biosynthetic process
GO:0043025 IEA neuronal cell body
GO:0046684 IEA response to pyrethroid
GO:0052314 IEA phytoalexin metabolic process
GO:0070062 IEA extracellular vesicular exosome
GO:0071312 IEA cellular response to alkaloid
GO:0071363 IEA cellular response to growth factor stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000016494 ddc dopa decarboxylase protein_coding Danio_rerio
ENSG00000132437 DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) protein_coding Homo_sapiens

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