C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: lysine (K)-specific demethylase 6B
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000132510 KDM6B 9606 + 17:7839904-7854796 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000254846 KDM6B-001 7839904-7854796 protein_coding
  ENST00000448097 KDM6B-002 7839962-7853680 protein_coding
  ENST00000570632 KDM6B-003 7844915-7847571 protein_coding
  ENST00000571047 KDM6B-004 7839904-7845347 processed_transcript
  ENST00000572030 KDM6B-006 7839991-7840681 processed_transcript
  ENST00000575521 KDM6B-005 7844207-7844972 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000254846ENST00000448097ENST00000570632
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000254846 3.201±0.00 N/A N/A N/A 0.996±0.00 N/A N/A 1.594±0.00 0.217±0.00 10.662±0.00 7.432±3.54 2.495±0.71 5.950±0.00
ENST00000448097 2.288±0.00 1.277±0.00 0.327±0.00 N/A 2.283±0.12 1.047±0.00 0.119±0.00 1.166±0.97 N/A 3.497±3.14 5.625±4.53 N/A 2.893±0.00
ENST00000570632 N/A N/A 1.394±0.00 0.760±0.00 N/A N/A 0.523±0.00 0.888±0.00 1.294±0.00 1.399±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00037F CIL_00037F_0002 CGP 17:7717354-7854796
CIL_000322 CIL_000322_0002 CGP 17:7839904-7856099

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005515 IPI protein binding
GO:0005634 ISS nucleus
GO:0005654 TAS nucleoplasm
GO:0006954 IEA inflammatory response
GO:0008013 IEA beta-catenin binding
GO:0016577 IEA histone demethylation
GO:0043565 IEA sequence-specific DNA binding
GO:0045446 ISS endothelial cell differentiation
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046872 IEA metal ion binding
GO:0048333 ISS mesodermal cell differentiation
GO:0051213 IEA dioxygenase activity
GO:0055007 ISS cardiac muscle cell differentiation
GO:0055114 IEA oxidation-reduction process
GO:0070301 IEA cellular response to hydrogen peroxide
GO:0071557 IEA histone H3-K27 demethylation
GO:0071558 EXP histone demethylase activity (H3-K27 specific)

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000088087 KDM6B lysine (K)-specific demethylase 6B protein_coding Danio_rerio
ENSMUSG00000018476 Kdm6b KDM1 lysine (K)-specific demethylase 6B protein_coding Mus_musculus

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