C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: caspase 9, apoptosis-related cysteine peptidase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000132906 CASP9 9606 - 1:15490832-15526534 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000333868 CASP9-001 15492270-15524295 protein_coding
  ENST00000348549 CASP9-002 15492270-15524347 protein_coding
  ENST00000375890 CASP9-008 15492855-15524726 protein_coding
  ENST00000400777 CASP9-006 15492366-15524192 nonsense_mediated_decay
  ENST00000424908 CASP9-007 15492798-15507052 protein_coding
  ENST00000440484 CASP9-005 15504625-15524217 protein_coding
  ENST00000447522 CASP9-003 15495273-15524889 protein_coding
  ENST00000469637 CASP9-004 15518136-15526534 protein_coding
  ENST00000474305 CASP9-011 15492943-15524200 nonsense_mediated_decay
  ENST00000546424 CASP9-009 15490832-15524445 protein_coding
  ENST00000546969 CASP9-012 15507772-15524215 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000333868ENST00000348549ENST00000400777ENST00000424908ENST00000447522ENST00000469637ENST00000474305ENST00000546424ENST00000546969
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000333868 N/A 1.190±0.00 N/A 1.032±0.00 0.573±0.10 N/A N/A 1.158±0.00 N/A 2.333±0.00 N/A 8.289±3.28 4.169±0.31 9.764±7.30
ENST00000348549 N/A N/A N/A 1.234±0.00 N/A 1.406±0.00 1.474±0.00 1.126±0.00 0.621±0.02 N/A 0.740±0.47 3.341±2.02 1.426±0.12 N/A
ENST00000400777 1.247±0.00 N/A N/A 1.357±0.00 1.649±0.00 1.338±0.00 1.578±0.00 2.216±0.00 1.671±0.00 3.372±0.00 1.503±0.00 8.697±0.00 3.922±0.00 5.670±2.59
ENST00000424908 N/A N/A 0.840±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000447522 0.956±0.00 N/A N/A N/A 0.497±0.00 N/A N/A N/A 1.048±0.00 0.665±0.00 N/A 1.706±0.00 N/A N/A
ENST00000469637 N/A N/A 1.494±0.00 N/A N/A N/A N/A N/A 1.059±0.00 N/A N/A 1.823±0.00 N/A N/A
ENST00000474305 N/A N/A N/A N/A N/A 1.284±0.00 N/A N/A N/A 0.534±0.00 N/A N/A N/A N/A
ENST00000546424 N/A N/A N/A N/A N/A N/A 0.095±0.00 N/A N/A N/A N/A 1.669±0.00 N/A N/A
ENST00000546969 N/A N/A N/A 1.475±0.00 1.529±0.00 1.486±0.00 N/A 2.120±0.00 N/A N/A 0.437±0.00 N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004197 IBA:IEA cysteine-type endopeptidase activity
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0005739 IEA mitochondrion
GO:0005829 IDA cytosol
GO:0006508 IEA proteolysis
GO:0006915 TAS:IEA apoptotic process
GO:0006919 IEA activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006974 IDA cellular response to DNA damage stimulus
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007568 IEA aging
GO:0008047 TAS enzyme activator activity
GO:0008233 IDA peptidase activity
GO:0008234 IEA cysteine-type peptidase activity
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0008630 IMP intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008635 TAS activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0009411 IEA response to UV
GO:0014070 IEA response to organic cyclic compound
GO:0017124 IDA SH3 domain binding
GO:0019901 IDA protein kinase binding
GO:0030220 TAS platelet formation
GO:0032025 IEA response to cobalt ion
GO:0032355 IEA response to estradiol
GO:0032496 IEA response to lipopolysaccharide
GO:0034349 IEA glial cell apoptotic process
GO:0034644 IDA cellular response to UV
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042770 IDA signal transduction in response to DNA damage
GO:0042981 TAS:IEA regulation of apoptotic process
GO:0043065 TAS positive regulation of apoptotic process
GO:0043293 IDA apoptosome
GO:0043525 IEA positive regulation of neuron apoptotic process
GO:0045087 TAS innate immune response
GO:0046677 IEA response to antibiotic
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0071407 IEA cellular response to organic cyclic compound
GO:0071549 IEA cellular response to dexamethasone stimulus
GO:0097193 TAS intrinsic apoptotic signaling pathway
GO:2001020 IMP regulation of response to DNA damage stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000004325 casp9 caspase 9, apoptosis-related cysteine protease protein_coding Danio_rerio
ENSMUSG00000028914 Casp9 caspase 9 protein_coding Mus_musculus

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