C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: dedicator of cytokinesis 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000134516 DOCK2 9606 + 5:169637247-170083382 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000256935 DOCK2-001 169637247-170083382 protein_coding
  ENST00000433448 DOCK2-011 170008497-170034508 nonsense_mediated_decay
  ENST00000518056 DOCK2-012 170040635-170042060 retained_intron
  ENST00000519223 DOCK2-013 169695849-169702623 retained_intron
  ENST00000519628 DOCK2-015 169759717-169934871 protein_coding
  ENST00000519734 DOCK2-009 169695286-169700039 processed_transcript
  ENST00000519868 DOCK2-006 170075444-170083377 retained_intron
  ENST00000520181 DOCK2-017 169747426-169875877 processed_transcript
  ENST00000520450 DOCK2-005 170056438-170083377 retained_intron
  ENST00000520836 DOCK2-014 169718746-169841535 processed_transcript
  ENST00000520908 DOCK2-004 169703949-170083379 protein_coding
  ENST00000522138 DOCK2-007 169637286-169681865 processed_transcript
  ENST00000522994 DOCK2-010 169983108-170000471 processed_transcript
  ENST00000523351 DOCK2-016 169761307-170083377 processed_transcript
  ENST00000523684 DOCK2-008 169695179-169702427 processed_transcript
  ENST00000524185 DOCK2-002 169637291-170082934 nonsense_mediated_decay
  ENST00000540750 DOCK2-201 169702130-169875876 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000256935ENST00000519628ENST00000520450ENST00000520908ENST00000523351ENST00000524185
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000256935 1.963±0.00 3.234±0.00 N/A 0.317±0.06 0.968±0.11 2.504±0.00 0.246±0.00 0.367±0.00 0.791±0.00 4.316±1.78 N/A 0.677±0.13 1.762±0.73 0.682±0.00
ENST00000519628 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.211±0.00 N/A N/A N/A
ENST00000520450 N/A 5.904±0.00 N/A N/A N/A N/A N/A N/A N/A 2.150±0.00 0.256±0.00 0.562±0.07 N/A 0.800±0.00
ENST00000520908 N/A N/A N/A N/A 0.344±0.00 0.159±0.00 0.238±0.00 N/A N/A 2.171±0.00 N/A 0.522±0.00 1.335±0.00 N/A
ENST00000523351 2.341±0.00 6.225±0.00 N/A N/A 1.072±0.00 N/A 0.370±0.00 0.715±0.00 N/A N/A N/A 0.551±0.25 1.227±0.29 0.525±0.00
ENST00000524185 N/A N/A 0.137±0.00 0.514±0.00 2.141±0.00 N/A 0.305±0.00 0.818±0.00 1.116±0.00 N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000OV CIL_0000OV_0002 CGP 5:169637247-170083382

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001766 IEA membrane raft polarization
GO:0001768 IEA establishment of T cell polarity
GO:0001771 IEA immunological synapse formation
GO:0002277 ISS myeloid dendritic cell activation involved in immune response
GO:0005085 IEA guanyl-nucleotide exchange factor activity
GO:0005488 IEA binding
GO:0005515 IPI:IEA protein binding
GO:0005829 TAS cytosol
GO:0005856 IEA cytoskeleton
GO:0006935 IEA chemotaxis
GO:0007010 IEA cytoskeleton organization
GO:0007264 IEA small GTPase mediated signal transduction
GO:0009055 IEA electron carrier activity
GO:0016020 IDA membrane
GO:0016032 TAS viral process
GO:0020037 IEA heme binding
GO:0030036 TAS actin cytoskeleton organization
GO:0030675 IEA Rac GTPase activator activity
GO:0030676 IDA Rac guanyl-nucleotide exchange factor activity
GO:0042098 IEA T cell proliferation
GO:0042110 IEA T cell activation
GO:0042608 IDA T cell receptor binding
GO:0043547 IEA positive regulation of GTPase activity
GO:0044351 ISS macropinocytosis
GO:0045059 IEA positive thymic T cell selection
GO:0045060 IEA negative thymic T cell selection
GO:0046631 IEA alpha-beta T cell activation
GO:0046633 IEA alpha-beta T cell proliferation
GO:0050690 TAS regulation of defense response to virus by virus
GO:0050766 ISS positive regulation of phagocytosis
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000076562 DOCK2 dedicator of cytokinesis 2 protein_coding Danio_rerio
ENSMUSG00000020143 Dock2 dedicator of cyto-kinesis 2 protein_coding Mus_musculus

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