C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: dedicator of cyto-kinesis 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000020143 Dock2 10090 - 11:34226815-34783892 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000093193 Dock2-001 34226815-34783892 protein_coding
  ENSMUST00000101364 Dock2-201 34361959-34688479 protein_coding
  ENSMUST00000101365 Dock2-002 34273045-34783892 protein_coding
  ENSMUST00000127846 Dock2-004 34230559-34231670 retained_intron
  ENSMUST00000143540 Dock2-005 34437312-34783892 nonsense_mediated_decay
  ENSMUST00000154178 Dock2-006 34437312-34783883 retained_intron
  ENSMUST00000157036 Dock2-003 34307651-34312637 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000093193ENSMUST00000101365ENSMUST00000143540
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000093193 2.279±0.71 0.557±0.19 1.134±0.03 0.172±0.08 10.892±3.48 0.890±0.24 0.512±0.22 0.987±0.45 1.433±0.95 3.603±1.63 0.251±0.36 1.031±0.43 0.292±0.14 0.656±0.00
ENSMUST00000101365 N/A 0.329±0.00 N/A N/A N/A N/A 0.487±0.00 N/A 0.178±0.00 1.717±0.00 N/A N/A 0.053±0.00 N/A
ENSMUST00000143540 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.419±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000OV CIL_0000OV_0003 CGP 11:34226815-34783892

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001766 IMP membrane raft polarization
GO:0001768 IMP establishment of T cell polarity
GO:0001771 IMP immunological synapse formation
GO:0002277 IMP myeloid dendritic cell activation involved in immune response
GO:0005085 IEA guanyl-nucleotide exchange factor activity
GO:0005737 IEA cytoplasm
GO:0005856 IEA cytoskeleton
GO:0006935 IMP chemotaxis
GO:0007010 IDA cytoskeleton organization
GO:0007264 IEA small GTPase mediated signal transduction
GO:0016020 IEA membrane
GO:0030675 IMP Rac GTPase activator activity
GO:0030676 ISS Rac guanyl-nucleotide exchange factor activity
GO:0032855 ISS positive regulation of Rac GTPase activity
GO:0035022 IC positive regulation of Rac protein signal transduction
GO:0042098 IMP T cell proliferation
GO:0042110 IMP T cell activation
GO:0042608 ISS T cell receptor binding
GO:0044351 IMP macropinocytosis
GO:0045059 IMP positive thymic T cell selection
GO:0045060 IMP negative thymic T cell selection
GO:0046631 IMP alpha-beta T cell activation
GO:0046633 IMP alpha-beta T cell proliferation
GO:0050766 IMP positive regulation of phagocytosis
GO:0070062 IEA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000076562 DOCK2 dedicator of cytokinesis 2 protein_coding Danio_rerio
ENSG00000134516 DOCK2 dedicator of cytokinesis 2 protein_coding Homo_sapiens

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