C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: dedicator of cytokinesis 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000256935 DOCK2-001 ENSG00000134516 9606 + 5:169637247-170083382 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000256935
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000256935 1.963±0.00 3.234±0.00 0.317±0.06 0.968±0.11 2.504±0.00 0.246±0.00 0.367±0.00 0.791±0.00 4.316±1.78 0.677±0.13 1.762±0.73 0.682±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000OV CIL_0000OV_0002 CGP 5:169637247-170083382

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001766 IEA membrane raft polarization
GO:0001768 IEA establishment of T cell polarity
GO:0001771 IEA immunological synapse formation
GO:0002277 ISS myeloid dendritic cell activation involved in immune response
GO:0005085 IEA guanyl-nucleotide exchange factor activity
GO:0005488 IEA binding
GO:0005515 IPI:IEA protein binding
GO:0005829 TAS cytosol
GO:0005856 IEA cytoskeleton
GO:0006935 IEA chemotaxis
GO:0007010 IEA cytoskeleton organization
GO:0007264 IEA small GTPase mediated signal transduction
GO:0009055 IEA electron carrier activity
GO:0016020 IDA membrane
GO:0016032 TAS viral process
GO:0020037 IEA heme binding
GO:0030036 TAS actin cytoskeleton organization
GO:0030675 IEA Rac GTPase activator activity
GO:0030676 IDA Rac guanyl-nucleotide exchange factor activity
GO:0042098 IEA T cell proliferation
GO:0042110 IEA T cell activation
GO:0042608 IDA T cell receptor binding
GO:0044351 ISS macropinocytosis
GO:0045059 IEA positive thymic T cell selection
GO:0045060 IEA negative thymic T cell selection
GO:0046631 IEA alpha-beta T cell activation
GO:0046633 IEA alpha-beta T cell proliferation
GO:0050690 TAS regulation of defense response to virus by virus
GO:0050766 ISS positive regulation of phagocytosis
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000093193 Dock2-001 protein_coding Mus_musculus 0 7003
ENSMUST00000101365 Dock2-002 protein_coding Mus_musculus 0 4446
ENSMUST00000154178 Dock2-006 retained_intron Mus_musculus 0 3500
ENSMUST00000143540 Dock2-005 nonsense_mediated_decay Mus_musculus 0 2523
ENSMUST00000101364 Dock2-201 protein_coding Mus_musculus 0 874
ENSMUST00000084488 Dock1-201 protein_coding Mus_musculus 2e-32 147

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