C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ADAM metallopeptidase with thrombospondin type 1 motif, 8
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000134917 ADAMTS8 9606 - 11:130404925-130428993 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000257359 ADAMTS8-001 130404925-130428993 protein_coding
  ENST00000531752 ADAMTS8-005 130404925-130412113 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000257359ENST00000531752
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000257359 0.339±0.00 0.854±0.00 1.890±0.69 0.186±0.02 2.441±2.06 0.236±0.00 2.622±0.00 0.134±0.11 31.699±29.88 N/A 1.716±0.94 4.541±0.40 0.969±0.00
ENST00000531752 N/A N/A 0.696±0.20 0.421±0.27 0.985±0.00 0.037±0.00 N/A 0.443±0.00 0.737±0.00 0.093±0.00 0.193±0.02 N/A 0.186±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000517 CIL_000517_0002 CGP 11:130226677-130428993
CIL_000516 CIL_000516_0002 CGP 11:130404925-130476641

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004222 IEA metalloendopeptidase activity
GO:0005178 TAS integrin binding
GO:0005578 IEA proteinaceous extracellular matrix
GO:0006508 IEA proteolysis
GO:0008201 IEA heparin binding
GO:0008237 TAS metallopeptidase activity
GO:0008270 IEA zinc ion binding
GO:0008285 TAS negative regulation of cell proliferation
GO:0009673 TAS low-affinity phosphate transmembrane transporter activity
GO:0031012 ISS:IEA extracellular matrix
GO:0035435 TAS phosphate ion transmembrane transport

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000007709 adamts8a ADAM metallopeptidase with thrombospondin type 1 motif, 8a protein_coding Danio_rerio
ENSDARG00000058252 adamts15b ADAM metallopeptidase with thrombospondin type 1 motif, 15b protein_coding Danio_rerio
ENSMUSG00000031994 Adamts8 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8 protein_coding Mus_musculus

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