C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cathepsin L
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000135047 CTSL 9606 + 9:87725519-87731393 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000340342 CTSL-002 87726109-87731386 protein_coding
  ENST00000342020 CTSL-004 87726140-87728997 protein_coding
  ENST00000343150 CTSL-001 87725519-87731392 protein_coding
  ENST00000375894 CTSL-005 87726114-87731073 processed_transcript
  ENST00000482054 CTSL-006 87726140-87729680 processed_transcript
  ENST00000495822 CTSL-003 87726134-87731393 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000340342ENST00000343150ENST00000375894ENST00000482054ENST00000495822
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000340342 44.300±0.00 49.423±0.00 4.589±0.00 18.126±9.69 18.546±10.55 19.540±16.59 14.577±9.83 74.269±48.46 47.728±40.86 35.437±27.74 7.485±0.00 72.452±44.61 535.247±157.49 73.001±31.95
ENST00000343150 N/A N/A 2.174±0.00 2.900±0.00 2.907±0.00 4.499±3.60 3.515±2.45 6.164±0.00 3.420±0.00 6.342±4.30 1.122±0.14 9.430±5.30 50.624±0.00 N/A
ENST00000375894 24.774±0.00 16.520±0.00 N/A N/A 19.794±0.00 24.933±0.00 12.921±0.00 51.210±0.00 35.807±0.00 33.020±0.00 2.820±0.00 N/A N/A 22.130±0.00
ENST00000482054 N/A N/A 4.268±0.00 N/A 4.058±0.00 1.735±0.00 1.415±0.00 N/A 7.049±0.00 3.036±0.00 1.759±0.00 7.843±0.00 N/A N/A
ENST00000495822 N/A N/A N/A N/A N/A 1.165±0.00 N/A N/A N/A N/A 4.517±0.00 94.091±0.00 355.157±0.00 59.193±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001968 IPI fibronectin binding
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002250 IEP adaptive immune response
GO:0004197 IDA cysteine-type endopeptidase activity
GO:0005515 IPI protein binding
GO:0005518 IDA collagen binding
GO:0005576 NAS extracellular region
GO:0005615 IDA extracellular space
GO:0005634 TAS nucleus
GO:0005764 IDA lysosome
GO:0006508 IDA:IEA proteolysis
GO:0008234 IDA:IEA cysteine-type peptidase activity
GO:0019882 TAS antigen processing and presentation
GO:0019886 TAS antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0022617 TAS extracellular matrix disassembly
GO:0030198 TAS extracellular matrix organization
GO:0030574 IDA collagen catabolic process
GO:0036021 TAS endolysosome lumen
GO:0042393 IDA histone binding
GO:0043202 TAS lysosomal lumen
GO:0043394 IPI proteoglycan binding
GO:0045087 TAS innate immune response
GO:0051603 IDA proteolysis involved in cellular protein catabolic process
GO:0070062 IDA extracellular vesicular exosome
GO:0071888 NAS macrophage apoptotic process
GO:0097067 IEP cellular response to thyroid hormone stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000011701 ctsll cathepsin L, like protein_coding Danio_rerio
ENSDARG00000039173 ctslb cathepsin Lb protein_coding Danio_rerio
ENSDARG00000074306 ctslb cathepsin Lb protein_coding Danio_rerio
ENSDARG00000075527 si:dkey-269i1.3 si:dkey-269i1.3 protein_coding Danio_rerio
ENSDARG00000079376 zgc:174153 zgc:174153 protein_coding Danio_rerio
ENSDARG00000087651 ctslb cathepsin Lb protein_coding Danio_rerio
ENSDARG00000089750 si:dkey-26g8.5 si:dkey-26g8.5 protein_coding Danio_rerio
ENSDARG00000089806 si:dkey-239j18.3 si:dkey-239j18.3 protein_coding Danio_rerio
ENSDARG00000090918 si:dkey-269i1.4 si:dkey-269i1.4 protein_coding Danio_rerio
ENSDARG00000094559 zgc:174855 zgc:174855 protein_coding Danio_rerio
ENSDARG00000095072 si:dkey-26g8.4 si:dkey-26g8.4 protein_coding Danio_rerio
ENSDARG00000095254 si:dkey-239j18.2 si:dkey-239j18.2 protein_coding Danio_rerio
ENSDARG00000095744 si:dkey-269i1.4 si:dkey-269i1.4 protein_coding Danio_rerio

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