C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitogen-activated protein kinase kinase kinase 7
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000135341 MAP3K7 9606 - 6:90513573-90587045 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000369320 MAP3K7-006 90515683-90553464 protein_coding
  ENST00000369325 MAP3K7-003 90513573-90586883 protein_coding
  ENST00000369327 MAP3K7-004 90513573-90586889 protein_coding
  ENST00000369329 MAP3K7-002 90513573-90587045 protein_coding
  ENST00000369332 MAP3K7-001 90513573-90587045 protein_coding
  ENST00000479630 MAP3K7-005 90515634-90537218 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000369320ENST00000369325ENST00000369327ENST00000369329ENST00000369332ENST00000479630
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000369320 N/A N/A 0.511±0.00 1.153±0.00 1.435±0.00 0.623±0.00 N/A 0.361±0.00 1.120±0.00 2.585±0.00 N/A N/A N/A N/A
ENST00000369325 N/A N/A N/A N/A N/A N/A N/A 0.861±0.00 N/A N/A N/A N/A N/A 0.948±0.00
ENST00000369327 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.737±0.00 N/A N/A N/A
ENST00000369329 0.820±0.00 3.203±0.00 N/A 2.646±0.00 1.050±0.09 1.760±0.00 0.861±0.00 2.330±2.08 1.065±0.00 2.538±0.00 N/A 1.771±0.00 1.468±0.87 1.771±0.84
ENST00000369332 3.445±0.00 1.211±0.00 N/A 2.704±0.22 2.372±1.46 3.807±0.00 2.875±1.59 N/A 1.506±0.46 1.940±0.25 2.021±1.29 3.536±2.47 3.580±0.41 3.317±0.32
ENST00000479630 N/A 2.624±0.00 0.519±0.00 1.497±0.00 N/A 1.122±0.00 0.665±0.00 1.927±0.00 1.197±0.00 1.763±0.00 N/A 2.516±0.68 N/A 3.338±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008MG CIL_0008MG_0001 VISTA 6:89917263-90520553
CIL_0001Y5 CIL_0001Y5_0002 CGP 6:89926529-90587045

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 IEA MAPK cascade
GO:0000186 IDA activation of MAPKK activity
GO:0000187 IDA activation of MAPK activity
GO:0000287 IEA magnesium ion binding
GO:0001525 IEA angiogenesis
GO:0001841 IEA neural tube formation
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002726 IMP positive regulation of T cell cytokine production
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0004672 IDA:IEA protein kinase activity
GO:0004674 TAS protein serine/threonine kinase activity
GO:0004708 IEA MAP kinase kinase activity
GO:0004709 IDA MAP kinase kinase kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005671 IDA Ada2/Gcn5/Ada3 transcription activator complex
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005886 IEA plasma membrane
GO:0006351 IEA transcription, DNA-templated
GO:0006468 IEA protein phosphorylation
GO:0006915 IEA apoptotic process
GO:0007165 IEA signal transduction
GO:0007179 IEA transforming growth factor beta receptor signaling pathway
GO:0007249 TAS I-kappaB kinase/NF-kappaB signaling
GO:0007250 IMP activation of NF-kappaB-inducing kinase activity
GO:0007252 IDA I-kappaB phosphorylation
GO:0007254 IDA JNK cascade
GO:0008385 IPI IkappaB kinase complex
GO:0010008 TAS endosome membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0032743 IMP positive regulation of interleukin-2 production
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0035872 TAS nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0043123 IMP positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043507 IMP positive regulation of JUN kinase activity
GO:0043966 IDA histone H3 acetylation
GO:0045087 TAS innate immune response
GO:0046330 IEA positive regulation of JNK cascade
GO:0050852 NAS T cell receptor signaling pathway
GO:0050870 IC positive regulation of T cell activation
GO:0051092 TAS positive regulation of NF-kappaB transcription factor activity
GO:0051403 IDA stress-activated MAPK cascade
GO:0070423 TAS nucleotide-binding oligomerization domain containing signaling pathway
GO:0097110 IDA scaffold protein binding
GO:1902443 IEA negative regulation of ripoptosome assembly involved in necroptotic process
GO:2000377 IEA regulation of reactive oxygen species metabolic process
GO:2001234 IEA negative regulation of apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000020469 map3k7 mitogen activated protein kinase kinase kinase 7 protein_coding Danio_rerio
ENSMUSG00000028284 Map3k7 mitogen-activated protein kinase kinase kinase 7 protein_coding Mus_musculus

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