C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitogen-activated protein kinase kinase kinase 7
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000028284 Map3k7 10090 + 4:31964097-32023467 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000037607 Map3k7-001 31964097-32023467 protein_coding
  ENSMUST00000080933 Map3k7-002 31964120-32023467 protein_coding
  ENSMUST00000108183 Map3k7-003 31964257-32023467 protein_coding
  ENSMUST00000108184 Map3k7-004 31964263-32023467 protein_coding
  ENSMUST00000126632 Map3k7-008 31981576-31992775 processed_transcript
  ENSMUST00000131114 Map3k7-005 31977348-31988641 processed_transcript
  ENSMUST00000131310 Map3k7-009 31992473-32019560 processed_transcript
  ENSMUST00000143138 Map3k7-006 31979498-31985721 processed_transcript
  ENSMUST00000147462 Map3k7-007 31985667-32015970 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000037607ENSMUST00000080933ENSMUST00000108184ENSMUST00000131310
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000037607 6.660±0.92 8.035±2.62 5.546±0.67 2.748±1.30 6.457±1.47 10.522±0.64 5.577±1.09 8.940±1.24 7.014±1.69 6.230±1.19 N/A 9.119±3.27 6.561±3.94 3.596±1.58
ENSMUST00000080933 5.623±2.76 5.005±2.13 7.975±1.19 8.901±3.02 5.048±0.91 2.287±0.24 3.016±0.35 1.722±0.15 2.042±0.75 5.477±0.40 10.998±0.27 7.077±2.40 4.019±0.80 0.966±0.00
ENSMUST00000108184 N/A N/A N/A N/A N/A N/A N/A N/A 3.599±0.25 N/A N/A N/A N/A N/A
ENSMUST00000131310 N/A 13.169±2.10 N/A N/A 16.589±4.36 N/A N/A N/A 9.168±0.72 N/A N/A N/A N/A 11.072±0.53

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 IDA MAPK cascade
GO:0000186 IEA activation of MAPKK activity
GO:0000187 IEA activation of MAPK activity
GO:0000287 IEA magnesium ion binding
GO:0001525 IMP angiogenesis
GO:0001841 IMP neural tube formation
GO:0002726 IEA positive regulation of T cell cytokine production
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004708 IDA MAP kinase kinase activity
GO:0004709 ISS MAP kinase kinase kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005671 IEA Ada2/Gcn5/Ada3 transcription activator complex
GO:0005737 IEA cytoplasm
GO:0005886 IEA plasma membrane
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006468 IDA protein phosphorylation
GO:0006915 IEA apoptotic process
GO:0006950 IEA response to stress
GO:0007179 IMP transforming growth factor beta receptor signaling pathway
GO:0007250 IEA activation of NF-kappaB-inducing kinase activity
GO:0007252 IGI I-kappaB phosphorylation
GO:0007254 IEA JNK cascade
GO:0008385 IEA IkappaB kinase complex
GO:0032743 IEA positive regulation of interleukin-2 production
GO:0043123 IGI positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043507 IEA positive regulation of JUN kinase activity
GO:0043966 IEA histone H3 acetylation
GO:0046330 IGI positive regulation of JNK cascade
GO:0051403 IEA stress-activated MAPK cascade
GO:0060546 IMP negative regulation of necroptotic process
GO:0097110 ISO scaffold protein binding
GO:1902443 IGI negative regulation of ripoptosome assembly involved in necroptotic process
GO:2000377 IMP regulation of reactive oxygen species metabolic process
GO:2000378 IMP negative regulation of reactive oxygen species metabolic process
GO:2001234 IGI negative regulation of apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000020469 map3k7 mitogen activated protein kinase kinase kinase 7 protein_coding Danio_rerio
ENSG00000135341 MAP3K7 mitogen-activated protein kinase kinase kinase 7 protein_coding Homo_sapiens

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