C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: hes-related family bHLH transcription factor with YRPW motif 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000135547 HEY2 9606 + 6:125747664-125761269 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000368364 HEY2-001 125749580-125761269 protein_coding
  ENST00000368365 HEY2-002 125747664-125761269 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000368364ENST00000368365
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000368364 1.304±0.00 1.079±0.00 N/A 1.388±0.36 1.818±1.52 0.713±0.56 4.255±2.00 1.388±0.00 0.557±0.14 0.964±0.44 2.699±0.38 1.711±1.16 1.337±0.46 6.591±0.09
ENST00000368365 N/A N/A 0.603±0.00 N/A 0.055±0.00 0.283±0.00 N/A 1.301±0.00 0.215±0.00 0.254±0.00 N/A 0.515±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008OD CIL_0008OD_0001 VISTA 6:125236534-125837593
CIL_0008OI CIL_0008OI_0001 VISTA 6:125254869-125857286
CIL_0008OH CIL_0008OH_0001 VISTA 6:125258053-125858974
CIL_0008OG CIL_0008OG_0001 VISTA 6:125287797-125889208

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000983 ISS RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity
GO:0000988 IDA protein binding transcription factor activity
GO:0001102 IPI RNA polymerase II activating transcription factor binding
GO:0001568 IEA blood vessel development
GO:0001570 ISS vasculogenesis
GO:0003150 ISS muscular septum morphogenesis
GO:0003151 ISS outflow tract morphogenesis
GO:0003171 IEA atrioventricular valve development
GO:0003184 ISS pulmonary valve morphogenesis
GO:0003186 ISS tricuspid valve morphogenesis
GO:0003195 IEA tricuspid valve formation
GO:0003199 IEA endocardial cushion to mesenchymal transition involved in heart valve formation
GO:0003208 ISS cardiac ventricle morphogenesis
GO:0003214 ISS cardiac left ventricle morphogenesis
GO:0003215 ISS cardiac right ventricle morphogenesis
GO:0003222 IEA ventricular trabecula myocardium morphogenesis
GO:0003300 IEA cardiac muscle hypertrophy
GO:0003677 IEA DNA binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IEA:ISS nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 ISS cytoplasm
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0007219 ISS Notch signaling pathway
GO:0007389 IEA pattern specification process
GO:0007507 IEA heart development
GO:0008134 NAS transcription factor binding
GO:0009948 IEA anterior/posterior axis specification
GO:0010460 IEA positive regulation of heart rate
GO:0010468 IEA regulation of gene expression
GO:0010621 ISS negative regulation of transcription by transcription factor localization
GO:0010629 ISS negative regulation of gene expression
GO:0010667 IEA negative regulation of cardiac muscle cell apoptotic process
GO:0014031 ISS mesenchymal cell development
GO:0014898 IEA cardiac muscle hypertrophy in response to stress
GO:0016580 IDA Sin3 complex
GO:0017053 IDA transcriptional repressor complex
GO:0035910 ISS ascending aorta morphogenesis
GO:0035912 ISS dorsal aorta morphogenesis
GO:0035939 IDA microsatellite binding
GO:0036304 ISS umbilical cord morphogenesis
GO:0042826 IPI histone deacetylase binding
GO:0043565 IDA sequence-specific DNA binding
GO:0045165 IEA cell fate commitment
GO:0045607 IEA regulation of auditory receptor cell differentiation
GO:0045746 IEA negative regulation of Notch signaling pathway
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046983 IEA protein dimerization activity
GO:0051145 NAS smooth muscle cell differentiation
GO:0055015 ISS ventricular cardiac muscle cell development
GO:0060045 IEA positive regulation of cardiac muscle cell proliferation
GO:0060317 ISS cardiac epithelial to mesenchymal transition
GO:0060347 IEA heart trabecula formation
GO:0060411 ISS cardiac septum morphogenesis
GO:0060412 ISS ventricular septum morphogenesis
GO:0060413 ISS atrial septum morphogenesis
GO:0060633 IDA negative regulation of transcription initiation from RNA polymerase II promoter
GO:0060716 ISS labyrinthine layer blood vessel development
GO:0060840 IEA artery development
GO:0060842 ISS arterial endothelial cell differentiation
GO:0060948 IEA cardiac vascular smooth muscle cell development
GO:0060977 IEA coronary vasculature morphogenesis
GO:0061156 ISS pulmonary artery morphogenesis
GO:0061314 IC Notch signaling involved in heart development
GO:0065004 IEA protein-DNA complex assembly
GO:0090102 IEA cochlea development
GO:0097084 IEP vascular smooth muscle cell development
GO:2000678 IDA negative regulation of transcription regulatory region DNA binding
GO:2000723 ISS negative regulation of cardiac vascular smooth muscle cell differentiation
GO:2000820 ISS negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
GO:2001212 ISS regulation of vasculogenesis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000013441 hey2 hairy/enhancer-of-split related with YRPW motif 2 protein_coding Danio_rerio
ENSMUSG00000019789 Hey2 hairy/enhancer-of-split related with YRPW motif 2 protein_coding Mus_musculus

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