C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: glutamate-ammonia ligase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000135821 GLUL 9606 - 1:182381704-182392206 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000311223 GLUL-201 182381705-182392206 protein_coding
  ENST00000331872 GLUL-001 182381704-182392206 protein_coding
  ENST00000339526 GLUL-002 182382894-182391792 protein_coding
  ENST00000417584 GLUL-202 182381705-182391404 protein_coding
  ENST00000461447 GLUL-010 182384415-182385939 processed_transcript
  ENST00000462444 GLUL-007 182386775-182391774 processed_transcript
  ENST00000463851 GLUL-004 182384196-182391759 processed_transcript
  ENST00000475808 GLUL-009 182386195-182389069 processed_transcript
  ENST00000480604 GLUL-006 182386273-182391759 processed_transcript
  ENST00000484996 GLUL-008 182385403-182391773 processed_transcript
  ENST00000489818 GLUL-005 182385699-182391790 processed_transcript
  ENST00000491322 GLUL-003 182382894-182390304 processed_transcript
  ENST00000621524 GLUL-203 182384338-182390539 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000331872ENST00000339526ENST00000417584ENST00000463851ENST00000480604ENST00000491322ENST00000621524
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000331872 N/A N/A N/A 39.938±0.00 N/A 8.928±0.00 2.995±0.00 42.629±0.00 N/A 16.966±0.00 8.927±0.00 19.233±0.00 N/A N/A
ENST00000339526 1120.530±0.00 149.578±0.00 N/A 1293.780±0.00 94.986±84.88 151.506±146.39 128.625±0.00 59.090±47.22 106.857±0.00 143.043±0.00 N/A 147.261±0.00 300.871±0.00 148.693±34.43
ENST00000417584 N/A N/A 1.414±0.00 103.545±0.00 20.198±0.00 6.265±0.00 N/A 10.779±0.00 N/A 13.561±0.00 13.633±0.00 N/A N/A N/A
ENST00000463851 N/A N/A N/A N/A N/A N/A N/A N/A 69.307±0.00 155.141±0.00 N/A N/A N/A N/A
ENST00000480604 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 150.017±0.00
ENST00000491322 N/A N/A 1.518±0.00 N/A 5.105±0.00 2.701±0.00 2.203±0.00 N/A 6.299±0.00 12.660±0.00 N/A 4.952±0.00 N/A N/A
ENST00000621524 N/A N/A 6.737±0.00 87.902±0.00 42.689±0.00 23.721±0.00 14.572±0.00 63.727±0.00 53.204±0.00 81.541±34.19 654.569±547.68 69.448±35.39 303.234±0.00 80.567±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007Y8 CIL_0007Y8_0001 VISTA 1:181935567-182536621

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000287 IEA magnesium ion binding
GO:0001504 TAS neurotransmitter uptake
GO:0004351 IEA glutamate decarboxylase activity
GO:0004356 EXP:IEA glutamate-ammonia ligase activity
GO:0005515 IEA protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005739 IEA mitochondrion
GO:0005791 IEA rough endoplasmic reticulum
GO:0005829 TAS cytosol
GO:0006536 IEA glutamate metabolic process
GO:0006538 TAS glutamate catabolic process
GO:0006542 TAS:IEA glutamine biosynthetic process
GO:0006807 IEA nitrogen compound metabolic process
GO:0007268 TAS synaptic transmission
GO:0008283 IDA cell proliferation
GO:0008652 TAS cellular amino acid biosynthetic process
GO:0009267 IEA cellular response to starvation
GO:0009749 IEA response to glucose
GO:0016595 IEA glutamate binding
GO:0030145 IEA manganese ion binding
GO:0032024 IEA positive regulation of insulin secretion
GO:0034641 TAS cellular nitrogen compound metabolic process
GO:0042802 IPI identical protein binding
GO:0042995 IEA cell projection
GO:0043005 IEA neuron projection
GO:0043204 IEA perikaryon
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0043234 IEA protein complex
GO:0043679 IEA axon terminus
GO:0044281 TAS small molecule metabolic process
GO:0044297 IEA cell body
GO:0045503 IEA dynein light chain binding
GO:0050679 IEA positive regulation of epithelial cell proliferation
GO:0051260 IEA protein homooligomerization
GO:0051968 IEA positive regulation of synaptic transmission, glutamatergic
GO:0070062 IDA extracellular vesicular exosome
GO:0097386 IEA glial cell projection

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000017339 glulb glutamate-ammonia ligase (glutamine synthase) b protein_coding Danio_rerio
ENSDARG00000069054 glula glutamate-ammonia ligase (glutamine synthase) a protein_coding Danio_rerio
ENSMUSG00000026473 Glul glutamate-ammonia ligase (glutamine synthetase) protein_coding Mus_musculus

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