C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Kruppel-like factor 4 (gut)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000136826 KLF4 9606 - 9:107484852-107490482 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000374672 KLF4-002 107484852-107489646 protein_coding
  ENST00000411706 KLF4-004 107487669-107489130 protein_coding
  ENST00000420475 KLF4-006 107488989-107490482 protein_coding
  ENST00000493306 KLF4-003 107484852-107489437 retained_intron
  ENST00000497048 KLF4-001 107484852-107488447 retained_intron
  ENST00000610832 KLF4-201 107484854-107489766 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000374672ENST00000420475ENST00000493306ENST00000497048ENST00000610832
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000374672 19.125±0.00 6.307±0.00 N/A N/A N/A N/A 8.266±0.00 N/A 1.374±0.71 22.094±0.00 8.292±0.00 13.204±4.84 15.123±6.12 5.715±1.09
ENST00000420475 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 6.591±0.00 N/A
ENST00000493306 N/A N/A N/A 1.099±0.00 N/A N/A 0.584±0.00 N/A N/A N/A N/A 5.367±3.33 N/A N/A
ENST00000497048 14.232±0.00 6.703±0.00 2.243±0.00 1.290±0.00 8.110±4.37 11.165±7.57 0.381±0.00 0.845±0.00 2.150±0.27 7.846±3.37 N/A 14.082±12.03 5.056±0.00 6.117±0.00
ENST00000610832 N/A N/A N/A 0.632±0.00 5.811±2.82 4.444±0.00 N/A 0.987±0.37 N/A 3.536±0.00 N/A 10.702±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000225 CIL_000225_0002 CGP 9:107283137-107490482
CIL_0001JU CIL_0001JU_0001 CGP 9:107484852-108856967

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000785 IEA chromatin
GO:0000790 IDA nuclear chromatin
GO:0000987 IDA core promoter proximal region sequence-specific DNA binding
GO:0001010 ISS sequence-specific DNA binding transcription factor recruiting transcription factor activity
GO:0001077 IMP RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001085 ISS RNA polymerase II transcription factor binding
GO:0001190 IDA RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0001221 IEA transcription cofactor binding
GO:0003690 IEA double-stranded DNA binding
GO:0003700 NAS sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005667 IEA transcription factor complex
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0006366 ISS transcription from RNA polymerase II promoter
GO:0007500 TAS mesodermal cell fate determination
GO:0008134 IEA transcription factor binding
GO:0008270 NAS zinc ion binding
GO:0008285 TAS negative regulation of cell proliferation
GO:0009913 IEA epidermal cell differentiation
GO:0010033 IEA response to organic substance
GO:0014067 IEA negative regulation of phosphatidylinositol 3-kinase signaling
GO:0014740 IEA negative regulation of muscle hyperplasia
GO:0019827 ISS stem cell maintenance
GO:0030154 IEA cell differentiation
GO:0031077 IEA post-embryonic camera-type eye development
GO:0032088 IDA negative regulation of NF-kappaB transcription factor activity
GO:0032270 IMP positive regulation of cellular protein metabolic process
GO:0032526 IEA response to retinoic acid
GO:0034115 IDA negative regulation of heterotypic cell-cell adhesion
GO:0035014 IEA phosphatidylinositol 3-kinase regulator activity
GO:0035166 IMP post-embryonic hemopoiesis
GO:0042127 IEA regulation of cell proliferation
GO:0043154 IDA negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043551 IEA regulation of phosphatidylinositol 3-kinase activity
GO:0043565 IEA sequence-specific DNA binding
GO:0044212 ISS transcription regulatory region DNA binding
GO:0045415 IDA negative regulation of interleukin-8 biosynthetic process
GO:0045429 IMP positive regulation of nitric oxide biosynthetic process
GO:0045444 ISS fat cell differentiation
GO:0045595 ISS regulation of cell differentiation
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046872 IEA metal ion binding
GO:0046985 IMP positive regulation of hemoglobin biosynthetic process
GO:0048662 IEA negative regulation of smooth muscle cell proliferation
GO:0048730 IEA epidermis morphogenesis
GO:0050728 TAS negative regulation of inflammatory response
GO:0051247 IGI positive regulation of protein metabolic process
GO:0051898 IEA negative regulation of protein kinase B signaling
GO:0060761 IDA negative regulation of response to cytokine stimulus
GO:0070301 IEA cellular response to hydrogen peroxide
GO:0070373 IEA negative regulation of ERK1 and ERK2 cascade
GO:0071363 IDA cellular response to growth factor stimulus
GO:0071407 IEA cellular response to organic cyclic compound
GO:0071409 IEA cellular response to cycloheximide
GO:0071499 IMP cellular response to laminar fluid shear stress
GO:0090051 IDA negative regulation of cell migration involved in sprouting angiogenesis
GO:1901653 IEA cellular response to peptide
GO:2000342 IDA negative regulation of chemokine (C-X-C motif) ligand 2 production

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000079922 klf4a Kruppel-like factor 4a protein_coding Danio_rerio
ENSMUSG00000003032 Klf4 Kruppel-like factor 4 (gut) protein_coding Mus_musculus

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