C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitogen-activated protein kinase kinase 5
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000137764 MAP2K5 9606 + 15:67542709-67807123 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000178640 MAP2K5-001 67542709-67807123 protein_coding
  ENST00000340972 MAP2K5-002 67640553-67807113 protein_coding
  ENST00000354498 MAP2K5-005 67548998-67807111 protein_coding
  ENST00000395476 MAP2K5-013 67543331-67807117 protein_coding
  ENST00000439036 MAP2K5-003 67563300-67641489 protein_coding
  ENST00000557869 MAP2K5-009 67703358-67769929 protein_coding
  ENST00000558021 MAP2K5-008 67748368-67769905 retained_intron
  ENST00000558274 MAP2K5-010 67717997-67806732 processed_transcript
  ENST00000558392 MAP2K5-007 67585742-67807083 retained_intron
  ENST00000559262 MAP2K5-006 67585890-67679956 protein_coding
  ENST00000560086 MAP2K5-012 67546153-67550075 processed_transcript
  ENST00000560591 MAP2K5-004 67543263-67659356 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000178640ENST00000354498ENST00000395476ENST00000439036ENST00000558392ENST00000559262ENST00000560591
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000178640 8.399±0.00 2.934±0.00 0.596±0.00 4.729±3.14 2.777±2.04 5.169±3.96 3.106±2.92 5.845±0.00 1.930±0.00 4.237±0.00 7.542±0.00 7.902±0.85 5.983±0.69 8.279±1.19
ENST00000354498 N/A N/A N/A 0.660±0.00 N/A 3.744±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000395476 N/A 1.753±0.00 N/A N/A 2.359±0.00 N/A N/A 0.760±0.58 1.044±0.00 1.526±0.00 1.789±0.00 1.332±0.74 3.692±1.81 N/A
ENST00000439036 N/A N/A N/A N/A N/A N/A N/A N/A 3.822±0.00 N/A 3.492±0.00 10.739±0.00 13.931±0.00 5.881±0.00
ENST00000558392 N/A N/A N/A 1.767±0.00 N/A N/A N/A N/A N/A N/A N/A 1.562±0.00 N/A 3.511±0.00
ENST00000559262 N/A N/A N/A N/A N/A N/A N/A 0.612±0.00 N/A N/A N/A N/A N/A N/A
ENST00000560591 N/A N/A 0.606±0.00 N/A N/A N/A N/A N/A 1.428±0.00 1.227±0.00 N/A 0.639±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007L5 CIL_0007L5_0001 UCNEbase 15:66906943-67787880
CIL_0008V3 CIL_0008V3_0001 VISTA 15:67072826-67673347
CIL_0008DX CIL_0008DX_0001 VISTA 15:67486945-68088375
CIL_00098T CIL_00098T_0001 VISTA 15:67539824-68142788

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 ISS negative regulation of transcription from RNA polymerase II promoter
GO:0000165 IEA MAPK cascade
GO:0000187 ISS activation of MAPK activity
GO:0004672 TAS:IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005819 IEA spindle
GO:0005829 IEA cytosol
GO:0006468 IEA protein phosphorylation
GO:0007165 TAS signal transduction
GO:0007507 IEA heart development
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0030307 IEA positive regulation of cell growth
GO:0032088 ISS negative regulation of NF-kappaB transcription factor activity
GO:0034115 ISS negative regulation of heterotypic cell-cell adhesion
GO:0043154 ISS negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045415 ISS negative regulation of interleukin-8 biosynthetic process
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046872 IEA metal ion binding
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0050679 IEA positive regulation of epithelial cell proliferation
GO:0051247 ISS positive regulation of protein metabolic process
GO:0060761 ISS negative regulation of response to cytokine stimulus
GO:0070375 IEA ERK5 cascade
GO:0071363 ISS cellular response to growth factor stimulus
GO:0071499 TAS cellular response to laminar fluid shear stress
GO:0090051 ISS negative regulation of cell migration involved in sprouting angiogenesis
GO:2000342 ISS negative regulation of chemokine (C-X-C motif) ligand 2 production
GO:2001240 ISS negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000011851 map2k5 mitogen-activated protein kinase kinase 5 protein_coding Danio_rerio
ENSMUSG00000058444 Map2k5 mitogen-activated protein kinase kinase 5 protein_coding Mus_musculus

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