C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: mitogen-activated protein kinase kinase 5
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000178640 MAP2K5-001 ENSG00000137764 9606 + 15:67542709-67807123 protein_coding

Homo sapiens EnsemblGRCh38

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Structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000178640
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000178640 8.399±0.00 2.934±0.00 0.596±0.00 4.729±3.14 2.777±2.04 5.169±3.96 3.106±2.92 5.845±0.00 1.930±0.00 4.237±0.00 7.542±0.00 7.902±0.85 5.983±0.69 8.279±1.19

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007L5 CIL_0007L5_0001 UCNEbase 15:66906943-67787880
CIL_0008V3 CIL_0008V3_0001 VISTA 15:67072826-67673347
CIL_0008DX CIL_0008DX_0001 VISTA 15:67486945-68088375
CIL_00098T CIL_00098T_0001 VISTA 15:67539824-68142788

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 ISS negative regulation of transcription from RNA polymerase II promoter
GO:0000165 IEA MAPK cascade
GO:0000187 ISS activation of MAPK activity
GO:0004672 TAS:IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005819 IEA spindle
GO:0005829 IEA cytosol
GO:0006468 IEA protein phosphorylation
GO:0007165 TAS signal transduction
GO:0007507 IEA heart development
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0030307 IEA positive regulation of cell growth
GO:0032088 ISS negative regulation of NF-kappaB transcription factor activity
GO:0034115 ISS negative regulation of heterotypic cell-cell adhesion
GO:0043154 ISS negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045415 ISS negative regulation of interleukin-8 biosynthetic process
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046872 IEA metal ion binding
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0050679 IEA positive regulation of epithelial cell proliferation
GO:0051247 ISS positive regulation of protein metabolic process
GO:0060761 ISS negative regulation of response to cytokine stimulus
GO:0070375 IEA ERK5 cascade
GO:0071363 ISS cellular response to growth factor stimulus
GO:0071499 TAS cellular response to laminar fluid shear stress
GO:0090051 ISS negative regulation of cell migration involved in sprouting angiogenesis
GO:2000342 ISS negative regulation of chemokine (C-X-C motif) ligand 2 production
GO:2001240 ISS negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000034920 Map2k5-201 protein_coding Mus_musculus 0 1892

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