C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: thrombospondin 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000137801 THBS1 9606 + 15:39581079-39599466 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000260356 THBS1-001 39581093-39599466 protein_coding
  ENST00000397591 THBS1-002 39581079-39582407 protein_coding
  ENST00000466755 THBS1-005 39587452-39588472 retained_intron
  ENST00000484734 THBS1-008 39593045-39595529 retained_intron
  ENST00000490247 THBS1-006 39588848-39589843 retained_intron
  ENST00000497720 THBS1-007 39587431-39588785 retained_intron
  ENST00000559746 THBS1-003 39594068-39595551 retained_intron
  ENST00000560894 THBS1-009 39590928-39591618 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastHeartKidneyLiverLungMuscleOvaryPlacentaENST00000260356
Transcript ID Adipose Bladder Brain Breast Heart Kidney Liver Lung Muscle Ovary Placenta
ENST00000260356 19.375±0.00 18.397±0.00 0.622±0.00 53.112±0.00 2.831±0.00 1.337±0.00 15.042±11.46 21.360±0.00 2.652±0.96 26.327±7.67 18.206±14.52

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006QV CIL_0006QV_0001 CGP 15:39581079-39782830

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 IMP activation of MAPK activity
GO:0001666 NAS response to hypoxia
GO:0001786 IDA phosphatidylserine binding
GO:0001937 IMP negative regulation of endothelial cell proliferation
GO:0001948 NAS glycoprotein binding
GO:0001953 IDA negative regulation of cell-matrix adhesion
GO:0001968 IDA fibronectin binding
GO:0002040 IMP sprouting angiogenesis
GO:0002544 IEP chronic inflammatory response
GO:0002576 TAS platelet degranulation
GO:0002581 IDA negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0002605 IDA negative regulation of dendritic cell antigen processing and presentation
GO:0003151 IEA outflow tract morphogenesis
GO:0003197 IEA endocardial cushion development
GO:0003417 IEA growth plate cartilage development
GO:0005178 IMP integrin binding
GO:0005509 NAS:IEA calcium ion binding
GO:0005515 IPI:IEA protein binding
GO:0005576 TAS:IEA extracellular region
GO:0005577 IDA fibrinogen complex
GO:0005615 IDA extracellular space
GO:0005737 IEA cytoplasm
GO:0005783 ISS endoplasmic reticulum
GO:0006954 IEA inflammatory response
GO:0006955 IEP immune response
GO:0006986 IEA response to unfolded protein
GO:0007050 IDA cell cycle arrest
GO:0007155 NAS:IEA cell adhesion
GO:0007596 TAS blood coagulation
GO:0008201 IEA:IDA heparin binding
GO:0009612 IEA response to mechanical stimulus
GO:0009749 IDA response to glucose
GO:0009897 IDA external side of plasma membrane
GO:0009986 IDA cell surface
GO:0010595 IDA positive regulation of endothelial cell migration
GO:0010596 IDA negative regulation of endothelial cell migration
GO:0010748 IDA negative regulation of plasma membrane long-chain fatty acid transport
GO:0010751 IDA negative regulation of nitric oxide mediated signal transduction
GO:0010754 IDA negative regulation of cGMP-mediated signaling
GO:0010757 IDA negative regulation of plasminogen activation
GO:0010759 ISS positive regulation of macrophage chemotaxis
GO:0010763 IDA positive regulation of fibroblast migration
GO:0010811 IEA positive regulation of cell-substrate adhesion
GO:0016477 IDA cell migration
GO:0016525 IDA negative regulation of angiogenesis
GO:0016529 ISS sarcoplasmic reticulum
GO:0017134 IDA fibroblast growth factor binding
GO:0018149 IDA peptide cross-linking
GO:0030141 IDA secretory granule
GO:0030168 TAS platelet activation
GO:0030169 IDA low-density lipoprotein particle binding
GO:0030194 IDA positive regulation of blood coagulation
GO:0030198 TAS extracellular matrix organization
GO:0030335 IDA positive regulation of cell migration
GO:0030511 IDA positive regulation of transforming growth factor beta receptor signaling pathway
GO:0031012 IDA extracellular matrix
GO:0031091 IDA platelet alpha granule
GO:0031093 TAS platelet alpha granule lumen
GO:0032026 IDA response to magnesium ion
GO:0032570 TAS response to progesterone
GO:0032695 IDA negative regulation of interleukin-12 production
GO:0032914 ISS positive regulation of transforming growth factor beta1 production
GO:0033574 IEA response to testosterone
GO:0034605 NAS cellular response to heat
GO:0034976 ISS response to endoplasmic reticulum stress
GO:0040037 IDA negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042327 IMP positive regulation of phosphorylation
GO:0042493 IEP response to drug
GO:0042535 IDA positive regulation of tumor necrosis factor biosynthetic process
GO:0042802 NAS identical protein binding
GO:0043032 IDA positive regulation of macrophage activation
GO:0043066 IDA negative regulation of apoptotic process
GO:0043154 IDA negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043236 IDA laminin binding
GO:0043394 TAS proteoglycan binding
GO:0043536 IDA positive regulation of blood vessel endothelial cell migration
GO:0043537 IDA negative regulation of blood vessel endothelial cell migration
GO:0043652 IDA engulfment of apoptotic cell
GO:0045727 IDA positive regulation of translation
GO:0045766 IMP positive regulation of angiogenesis
GO:0048266 ISS behavioral response to pain
GO:0048514 IEA blood vessel morphogenesis
GO:0050431 ISS transforming growth factor beta binding
GO:0050840 IEA extracellular matrix binding
GO:0050921 IDA positive regulation of chemotaxis
GO:0051592 IDA response to calcium ion
GO:0051895 TAS negative regulation of focal adhesion assembly
GO:0051897 IDA positive regulation of protein kinase B signaling
GO:0051918 IDA negative regulation of fibrinolysis
GO:0070051 IDA fibrinogen binding
GO:0070052 IDA collagen V binding
GO:0070062 IDA extracellular vesicular exosome
GO:0071356 IEA cellular response to tumor necrosis factor
GO:0071363 IEA cellular response to growth factor stimulus
GO:0071636 IEA positive regulation of transforming growth factor beta production
GO:0071732 IEA cellular response to nitric oxide
GO:1902043 IDA positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000353 IDA positive regulation of endothelial cell apoptotic process
GO:2000379 IDA positive regulation of reactive oxygen species metabolic process
GO:2001237 TAS negative regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000010785 thbs1b thrombospondin 1b protein_coding Danio_rerio
ENSDARG00000063430 THBS1 (2 of 3) thrombospondin 1 protein_coding Danio_rerio
ENSDARG00000079066 THBS1 (3 of 3) thrombospondin 1 protein_coding Danio_rerio
ENSMUSG00000040152 Thbs1 thrombospondin 1 protein_coding Mus_musculus

Loading