C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: thrombospondin 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000040152 Thbs1 10090 + 2:118111876-118127133 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000039559 Thbs1-001 118111876-118127133 protein_coding
  ENSMUST00000142588 Thbs1-002 118122940-118123764 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000039559
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000039559 18.931±7.30 1.319±0.18 13.445±0.21 1.525±1.18 2.283±0.51 9.307±3.23 2.176±0.89 8.149±0.19 5.487±5.53 11.512±1.13 1.287±0.42 45.271±30.22 7.949±2.08 0.404±0.11

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006QV CIL_0006QV_0002 CGP 2:118111876-118256966

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 IEA activation of MAPK activity
GO:0001786 IEA phosphatidylserine binding
GO:0001937 IMP negative regulation of endothelial cell proliferation
GO:0001953 ISO negative regulation of cell-matrix adhesion
GO:0001968 IEA fibronectin binding
GO:0002040 IEA sprouting angiogenesis
GO:0002544 IEA chronic inflammatory response
GO:0002581 IEA negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0002605 IEA negative regulation of dendritic cell antigen processing and presentation
GO:0003151 IGI outflow tract morphogenesis
GO:0003197 IGI endocardial cushion development
GO:0003417 IGI growth plate cartilage development
GO:0005178 IEA integrin binding
GO:0005509 IEA calcium ion binding
GO:0005577 IEA fibrinogen complex
GO:0005615 IDA extracellular space
GO:0005737 IEA cytoplasm
GO:0006954 IMP inflammatory response
GO:0006955 IEA immune response
GO:0007050 IEA cell cycle arrest
GO:0007155 IEA cell adhesion
GO:0008201 ISO heparin binding
GO:0009612 IEA response to mechanical stimulus
GO:0009749 IEA response to glucose
GO:0009897 IEA external side of plasma membrane
GO:0009986 IEA cell surface
GO:0010595 IEA positive regulation of endothelial cell migration
GO:0010596 IEA negative regulation of endothelial cell migration
GO:0010748 IEA negative regulation of plasma membrane long-chain fatty acid transport
GO:0010751 ISO negative regulation of nitric oxide mediated signal transduction
GO:0010754 IEA negative regulation of cGMP-mediated signaling
GO:0010757 IEA negative regulation of plasminogen activation
GO:0010763 IEA positive regulation of fibroblast migration
GO:0010811 IDA positive regulation of cell-substrate adhesion
GO:0016477 IEA cell migration
GO:0016525 IDA negative regulation of angiogenesis
GO:0017134 IEA fibroblast growth factor binding
GO:0018149 IEA peptide cross-linking
GO:0030141 IEA secretory granule
GO:0030169 IEA low-density lipoprotein particle binding
GO:0030194 IEA positive regulation of blood coagulation
GO:0030335 IEA positive regulation of cell migration
GO:0030511 IEA positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030823 ISO regulation of cGMP metabolic process
GO:0031012 IEA extracellular matrix
GO:0031091 IEA platelet alpha granule
GO:0032026 IEA response to magnesium ion
GO:0032695 IEA negative regulation of interleukin-12 production
GO:0033574 IEA response to testosterone
GO:0040037 IEA negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042327 IEA positive regulation of phosphorylation
GO:0042493 IEA response to drug
GO:0042535 IEA positive regulation of tumor necrosis factor biosynthetic process
GO:0043032 IEA positive regulation of macrophage activation
GO:0043066 IEA negative regulation of apoptotic process
GO:0043154 IEA negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043236 IEA laminin binding
GO:0043536 IEA positive regulation of blood vessel endothelial cell migration
GO:0043537 IEA negative regulation of blood vessel endothelial cell migration
GO:0043652 IEA engulfment of apoptotic cell
GO:0045727 IEA positive regulation of translation
GO:0045766 IEA positive regulation of angiogenesis
GO:0048514 IGI blood vessel morphogenesis
GO:0050431 IEA transforming growth factor beta binding
GO:0050840 IDA extracellular matrix binding
GO:0050921 IEA positive regulation of chemotaxis
GO:0051592 IEA response to calcium ion
GO:0051897 IEA positive regulation of protein kinase B signaling
GO:0051918 IEA negative regulation of fibrinolysis
GO:0070051 IEA fibrinogen binding
GO:0070052 IEA collagen V binding
GO:0070062 IEA extracellular vesicular exosome
GO:0071356 IEA cellular response to tumor necrosis factor
GO:0071363 IEA cellular response to growth factor stimulus
GO:0071636 IEA positive regulation of transforming growth factor beta production
GO:0071732 IMP cellular response to nitric oxide
GO:1902043 IEA positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000353 IEA positive regulation of endothelial cell apoptotic process
GO:2000379 IEA positive regulation of reactive oxygen species metabolic process
GO:2001027 ISO negative regulation of endothelial cell chemotaxis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000010785 thbs1b thrombospondin 1b protein_coding Danio_rerio
ENSDARG00000063430 THBS1 (2 of 3) thrombospondin 1 protein_coding Danio_rerio
ENSDARG00000079066 THBS1 (3 of 3) thrombospondin 1 protein_coding Danio_rerio
ENSG00000137801 THBS1 thrombospondin 1 protein_coding Homo_sapiens

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