C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ADAM metallopeptidase domain 10
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000137845 ADAM10 9606 - 15:58588807-58749978 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000260408 ADAM10-001 58588807-58749978 protein_coding
  ENST00000396136 ADAM10-002 58597202-58679282 nonsense_mediated_decay
  ENST00000402627 ADAM10-006 58596872-58749594 protein_coding
  ENST00000439637 ADAM10-010 58665146-58749758 protein_coding
  ENST00000461408 ADAM10-003 58747345-58749719 protein_coding
  ENST00000462061 ADAM10-005 58610927-58621541 retained_intron
  ENST00000470269 ADAM10-007 58609158-58621510 retained_intron
  ENST00000475898 ADAM10-011 58611854-58629464 processed_transcript
  ENST00000481164 ADAM10-004 58611276-58621504 retained_intron
  ENST00000482945 ADAM10-008 58597165-58621504 retained_intron
  ENST00000497846 ADAM10-009 58665152-58748966 processed_transcript
  ENST00000558004 ADAM10-013 58665182-58749774 protein_coding
  ENST00000558733 ADAM10-015 58655243-58749770 processed_transcript
  ENST00000559053 ADAM10-016 58627712-58749630 protein_coding
  ENST00000560608 ADAM10-014 58679159-58749791 processed_transcript
  ENST00000561149 ADAM10-012 58682252-58749720 processed_transcript
  ENST00000561288 ADAM10-017 58597164-58749707 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000260408ENST00000396136ENST00000461408ENST00000475898ENST00000558733
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000260408 1.209±0.00 3.735±0.00 1.159±0.00 1.622±0.48 2.116±0.73 1.739±0.83 2.278±0.00 2.805±2.14 1.806±0.10 4.917±0.00 0.967±0.81 2.619±1.45 3.696±1.46 2.704±0.71
ENST00000396136 N/A 7.578±0.00 6.798±0.00 7.463±0.01 8.501±2.64 6.560±0.70 5.024±2.34 7.373±1.04 5.338±1.67 13.090±1.38 2.806±1.66 7.643±3.37 11.282±3.10 6.113±1.23
ENST00000461408 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.625±0.00 N/A N/A N/A
ENST00000475898 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 13.226±0.00 5.242±0.00
ENST00000558733 N/A N/A 9.834±0.00 6.037±0.00 7.747±0.00 10.754±0.00 N/A N/A 13.244±0.00 15.187±0.00 N/A 12.229±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008MN CIL_0008MN_0001 VISTA 15:58226062-58826684
CIL_000500 CIL_000500_0002 CGP 15:58588807-58861900

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001701 ISS in utero embryonic development
GO:0004175 ISS endopeptidase activity
GO:0004222 IMP:IEA metalloendopeptidase activity
GO:0005102 NAS receptor binding
GO:0005178 NAS integrin binding
GO:0005515 IPI protein binding
GO:0005634 ISS nucleus
GO:0005737 ISS cytoplasm
GO:0005794 IDA Golgi apparatus
GO:0005798 IDA Golgi-associated vesicle
GO:0005886 TAS plasma membrane
GO:0005925 IDA focal adhesion
GO:0006468 ISS protein phosphorylation
GO:0006508 IEA proteolysis
GO:0006509 IDA membrane protein ectodomain proteolysis
GO:0007162 IDA negative regulation of cell adhesion
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007219 ISS Notch signaling pathway
GO:0007220 TAS Notch receptor processing
GO:0007229 NAS integrin-mediated signaling pathway
GO:0007267 NAS cell-cell signaling
GO:0008219 IEA cell death
GO:0008237 IDA metallopeptidase activity
GO:0008270 IEA zinc ion binding
GO:0008284 IMP positive regulation of cell proliferation
GO:0009986 IDA cell surface
GO:0010820 IMP positive regulation of T cell chemotaxis
GO:0014069 IEA postsynaptic density
GO:0016020 IDA membrane
GO:0016021 NAS integral component of membrane
GO:0017124 IEA SH3 domain binding
GO:0019901 ISS protein kinase binding
GO:0022617 TAS extracellular matrix disassembly
GO:0030198 TAS extracellular matrix organization
GO:0030307 IMP positive regulation of cell growth
GO:0030335 IMP positive regulation of cell migration
GO:0030574 TAS collagen catabolic process
GO:0034612 IDA response to tumor necrosis factor
GO:0042117 IMP monocyte activation
GO:0042803 ISS protein homodimerization activity
GO:0051088 IMP PMA-inducible membrane protein ectodomain proteolysis
GO:0051089 IDA constitutive protein ectodomain proteolysis
GO:0070062 IDA extracellular vesicular exosome
GO:0097038 IDA perinuclear endoplasmic reticulum
GO:0097197 IDA tetraspanin-enriched microdomain

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000015502 adam10b a disintegrin and metalloprotease domain 10b protein_coding Danio_rerio
ENSDARG00000053468 adam10a a disintegrin and metalloprotease domain 10a protein_coding Danio_rerio
ENSMUSG00000054693 Adam10 a disintegrin and metallopeptidase domain 10 protein_coding Mus_musculus

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