C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: a disintegrin and metallopeptidase domain 10
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000054693 Adam10 10090 + 9:70678997-70780229 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000067880 Adam10-001 70678997-70780229 protein_coding
  ENSMUST00000140205 Adam10-002 70678997-70778382 nonsense_mediated_decay
  ENSMUST00000144537 Adam10-003 70679016-70748114 protein_coding
  ENSMUST00000145377 Adam10-004 70776053-70778378 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000067880ENSMUST00000140205ENSMUST00000144537
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000067880 12.036±3.61 4.135±0.93 25.178±0.63 12.746±4.79 13.686±2.89 9.509±2.76 5.479±0.23 9.497±0.84 17.760±16.28 14.447±1.63 3.148±0.57 12.325±6.81 27.698±6.18 2.777±1.30
ENSMUST00000140205 N/A 2.579±0.71 N/A 9.959±0.00 2.426±0.03 1.957±0.00 N/A 2.186±0.24 N/A N/A N/A 10.250±6.59 26.039±0.00 2.045±0.86
ENSMUST00000144537 N/A 18.680±7.52 N/A N/A 21.665±1.88 16.481±2.72 N/A N/A 2.675±0.68 20.465±0.00 N/A 24.670±8.44 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008MN CIL_0008MN_0002 VISTA 9:70534536-71135234
CIL_0004P1 CIL_0004P1_0002 CGP 9:70678997-70934808

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001701 IMP in utero embryonic development
GO:0004175 IDA endopeptidase activity
GO:0004222 ISS metalloendopeptidase activity
GO:0005515 IPI protein binding
GO:0005576 IEA extracellular region
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005794 ISS Golgi apparatus
GO:0005798 ISS Golgi-associated vesicle
GO:0005886 TAS plasma membrane
GO:0005925 IEA focal adhesion
GO:0006468 IDA protein phosphorylation
GO:0006509 ISS membrane protein ectodomain proteolysis
GO:0006913 NAS nucleocytoplasmic transport
GO:0007162 ISS negative regulation of cell adhesion
GO:0007219 IMP Notch signaling pathway
GO:0007220 NAS Notch receptor processing
GO:0008237 IMP metallopeptidase activity
GO:0008270 IEA zinc ion binding
GO:0008284 IEA positive regulation of cell proliferation
GO:0009986 ISS cell surface
GO:0010820 IEA positive regulation of T cell chemotaxis
GO:0014069 IDA postsynaptic density
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0017124 IEA SH3 domain binding
GO:0019901 IDA protein kinase binding
GO:0030307 IEA positive regulation of cell growth
GO:0030335 IEA positive regulation of cell migration
GO:0034612 IEA response to tumor necrosis factor
GO:0042117 IEA monocyte activation
GO:0042169 NAS SH2 domain binding
GO:0042803 IPI protein homodimerization activity
GO:0051088 IEA PMA-inducible membrane protein ectodomain proteolysis
GO:0051089 IEA constitutive protein ectodomain proteolysis
GO:0070062 IEA extracellular vesicular exosome
GO:0097038 IEA perinuclear endoplasmic reticulum
GO:0097197 IEA tetraspanin-enriched microdomain

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000015502 adam10b a disintegrin and metalloprotease domain 10b protein_coding Danio_rerio
ENSDARG00000053468 adam10a a disintegrin and metalloprotease domain 10a protein_coding Danio_rerio
ENSG00000137845 ADAM10 ADAM metallopeptidase domain 10 protein_coding Homo_sapiens

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