C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: ADAM metallopeptidase domain 10
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000260408 ADAM10-001 ENSG00000137845 9606 - 15:58588807-58749978 protein_coding

Homo sapiens EnsemblGRCh38

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Genes
Structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000260408
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000260408 1.209±0.00 3.735±0.00 1.159±0.00 1.622±0.48 2.116±0.73 1.739±0.83 2.278±0.00 2.805±2.14 1.806±0.10 4.917±0.00 0.967±0.81 2.619±1.45 3.696±1.46 2.704±0.71

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008MN CIL_0008MN_0001 VISTA 15:58226062-58826684
CIL_000500 CIL_000500_0002 CGP 15:58588807-58861900

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001701 ISS in utero embryonic development
GO:0004175 ISS endopeptidase activity
GO:0004222 IMP:IEA metalloendopeptidase activity
GO:0005102 NAS receptor binding
GO:0005178 NAS integrin binding
GO:0005515 IPI protein binding
GO:0005634 ISS nucleus
GO:0005737 ISS cytoplasm
GO:0005794 IDA Golgi apparatus
GO:0005798 IDA Golgi-associated vesicle
GO:0005886 TAS plasma membrane
GO:0005925 IDA focal adhesion
GO:0006468 ISS protein phosphorylation
GO:0006508 IEA proteolysis
GO:0006509 IDA membrane protein ectodomain proteolysis
GO:0007162 IDA negative regulation of cell adhesion
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007219 ISS Notch signaling pathway
GO:0007220 TAS Notch receptor processing
GO:0007229 NAS integrin-mediated signaling pathway
GO:0007267 NAS cell-cell signaling
GO:0008219 IEA cell death
GO:0008237 IDA metallopeptidase activity
GO:0008270 IEA zinc ion binding
GO:0008284 IMP positive regulation of cell proliferation
GO:0009986 IDA cell surface
GO:0010820 IMP positive regulation of T cell chemotaxis
GO:0014069 IEA postsynaptic density
GO:0016020 IDA membrane
GO:0016021 NAS integral component of membrane
GO:0017124 IEA SH3 domain binding
GO:0019901 ISS protein kinase binding
GO:0022617 TAS extracellular matrix disassembly
GO:0030198 TAS extracellular matrix organization
GO:0030307 IMP positive regulation of cell growth
GO:0030335 IMP positive regulation of cell migration
GO:0030574 TAS collagen catabolic process
GO:0034612 IDA response to tumor necrosis factor
GO:0042117 IMP monocyte activation
GO:0042803 ISS protein homodimerization activity
GO:0051088 IMP PMA-inducible membrane protein ectodomain proteolysis
GO:0051089 IDA constitutive protein ectodomain proteolysis
GO:0070062 IDA extracellular vesicular exosome
GO:0097038 IDA perinuclear endoplasmic reticulum
GO:0097197 IDA tetraspanin-enriched microdomain

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000067880 Adam10-001 protein_coding Mus_musculus 0 5485
ENSMUST00000140205 Adam10-002 nonsense_mediated_decay Mus_musculus 0 3382
ENSMUST00000145377 Adam10-004 retained_intron Mus_musculus 0 723
ENSMUST00000144537 Adam10-003 protein_coding Mus_musculus 0 448

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