C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: phosphodiesterase 5A, cGMP-specific
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000138735 PDE5A 9606 - 4:119494395-119628991 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000264805 PDE5A-002 119498541-119627633 protein_coding
  ENST00000354960 PDE5A-001 119494395-119628991 protein_coding
  ENST00000394439 PDE5A-201 119494397-119628084 protein_coding
  ENST00000420633 PDE5A-003 119596526-119628065 protein_coding
  ENST00000502912 PDE5A-004 119538781-119542002 processed_transcript
  ENST00000503412 PDE5A-005 119500823-119519099 protein_coding
  ENST00000508914 PDE5A-007 119552441-119562972 retained_intron
  ENST00000509612 PDE5A-009 119507653-119519642 retained_intron
  ENST00000512450 PDE5A-012 119519079-119527276 processed_transcript
  ENST00000512494 PDE5A-006 119502390-119505935 retained_intron
  ENST00000512739 PDE5A-008 119521000-119543297 processed_transcript
  ENST00000513594 PDE5A-011 119517060-119539098 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000264805ENST00000354960ENST00000394439
Transcript ID Adipose Adrenal Bladder Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000264805 N/A N/A 1.428±0.00 5.325±0.00 7.090±0.00 1.040±0.00 N/A 6.157±0.00 N/A 0.982±0.00 N/A N/A N/A
ENST00000354960 0.878±0.00 1.924±0.00 N/A 1.825±0.84 3.233±0.61 0.532±0.00 1.396±0.00 2.524±2.46 N/A 0.694±0.00 0.726±0.00 0.539±0.09 1.572±0.71
ENST00000394439 0.731±0.00 1.943±0.00 N/A 1.850±0.72 2.234±0.00 1.242±0.00 N/A 9.571±0.00 4.887±3.10 1.692±0.00 0.955±0.04 0.842±0.21 3.766±2.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006YP CIL_0006YP_0002 CGP 4:119494395-120067074

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004112 IEA cyclic-nucleotide phosphodiesterase activity
GO:0004114 NAS:IEA 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0005515 IEA protein binding
GO:0005575 ND cellular_component
GO:0005829 TAS cytosol
GO:0007165 IEA signal transduction
GO:0007596 TAS blood coagulation
GO:0010613 IEA positive regulation of cardiac muscle hypertrophy
GO:0030553 TAS cGMP binding
GO:0030823 IEA regulation of cGMP metabolic process
GO:0042130 IEA negative regulation of T cell proliferation
GO:0043406 IEA positive regulation of MAP kinase activity
GO:0046068 IEA cGMP metabolic process
GO:0046069 IEA cGMP catabolic process
GO:0046872 IEA metal ion binding
GO:0047555 IEA 3',5'-cyclic-GMP phosphodiesterase activity
GO:0055118 IEA negative regulation of cardiac muscle contraction
GO:0055119 IEA relaxation of cardiac muscle
GO:0060282 IEA positive regulation of oocyte development

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000051915 pde5ab phosphodiesterase 5A, cGMP-specific, b protein_coding Danio_rerio
ENSDARG00000056806 phosphodiesterase 5A, cGMP-specific protein_coding Danio_rerio
ENSMUSG00000053965 Pde5a phosphodiesterase 5A, cGMP-specific protein_coding Mus_musculus

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