C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: phosphodiesterase 5A, cGMP-specific
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000053965 Pde5a 10090 + 3:122729158-122859374 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000066728 Pde5a-201 122729158-122859374 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000066728
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000066728 5.561±5.01 2.847±0.93 55.524±1.67 0.783±0.49 0.708±0.38 1.909±0.21 0.397±0.28 0.696±0.34 0.551±0.50 13.502±8.22 0.338±0.14 3.001±2.30 0.812±0.70 0.254±0.14

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004112 IDA cyclic-nucleotide phosphodiesterase activity
GO:0004114 IMP 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0007165 IEA signal transduction
GO:0010613 IMP positive regulation of cardiac muscle hypertrophy
GO:0030553 IDA cGMP binding
GO:0030823 IGI regulation of cGMP metabolic process
GO:0042130 IMP negative regulation of T cell proliferation
GO:0043406 IMP positive regulation of MAP kinase activity
GO:0045745 IC positive regulation of G-protein coupled receptor protein signaling pathway
GO:0046068 IMP cGMP metabolic process
GO:0046069 IEA cGMP catabolic process
GO:0046872 IEA metal ion binding
GO:0047555 IEA 3',5'-cyclic-GMP phosphodiesterase activity
GO:0055118 IMP negative regulation of cardiac muscle contraction
GO:0055119 IMP relaxation of cardiac muscle
GO:0060282 IGI positive regulation of oocyte development

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000051915 pde5ab phosphodiesterase 5A, cGMP-specific, b protein_coding Danio_rerio
ENSDARG00000056806 phosphodiesterase 5A, cGMP-specific protein_coding Danio_rerio
ENSG00000138735 PDE5A phosphodiesterase 5A, cGMP-specific protein_coding Homo_sapiens

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