C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: 3-phosphoinositide dependent protein kinase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000140992 PDPK1 9606 + 16:2537964-2603188 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000268673 PDPK1-002 2538003-2601095 protein_coding
  ENST00000342085 PDPK1-001 2537964-2603188 protein_coding
  ENST00000389224 PDPK1-003 2538164-2597928 protein_coding
  ENST00000441549 PDPK1-013 2537997-2597920 protein_coding
  ENST00000460496 PDPK1-009 2557444-2561879 processed_transcript
  ENST00000461815 PDPK1-008 2550603-2565614 protein_coding
  ENST00000462923 PDPK1-016 2538005-2539521 processed_transcript
  ENST00000464702 PDPK1-010 2565553-2571341 processed_transcript
  ENST00000471311 PDPK1-011 2565606-2570818 processed_transcript
  ENST00000474706 PDPK1-006 2538020-2561530 nonsense_mediated_decay
  ENST00000478708 PDPK1-012 2581347-2583987 nonsense_mediated_decay
  ENST00000491073 PDPK1-005 2556896-2584064 retained_intron
  ENST00000492021 PDPK1-007 2538021-2561501 nonsense_mediated_decay
  ENST00000561962 PDPK1-017 2599441-2601630 processed_transcript
  ENST00000566659 PDPK1-015 2537979-2581661 protein_coding
  ENST00000569721 PDPK1-018 2598247-2598638 processed_transcript
  ENST00000570136 PDPK1-014 2538021-2562227 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBladderBrainBreastColonHeartKidneyLiverMuscleOvaryPlacentaTestisENST00000268673ENST00000342085ENST00000389224
Transcript ID Adrenal Bladder Brain Breast Colon Heart Kidney Liver Muscle Ovary Placenta Testis
ENST00000268673 N/A 0.999±0.00 N/A N/A 2.021±0.00 0.478±0.00 1.230±0.00 N/A 1.692±0.00 N/A N/A N/A
ENST00000342085 2.861±0.00 N/A 5.575±1.66 2.026±0.00 1.093±0.37 4.911±0.00 0.368±0.00 3.670±0.00 N/A 2.934±1.86 6.589±3.27 16.018±0.00
ENST00000389224 N/A N/A N/A 1.772±0.00 N/A 0.570±0.00 1.173±0.00 1.771±0.00 N/A N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003323 IEA type B pancreatic cell development
GO:0004672 IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004676 IDA 3-phosphoinositide-dependent protein kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005158 IEA insulin receptor binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006468 IDA:IEA protein phosphorylation
GO:0006469 IDA negative regulation of protein kinase activity
GO:0006972 IEA hyperosmotic response
GO:0007173 IMP epidermal growth factor receptor signaling pathway
GO:0007268 TAS synaptic transmission
GO:0007596 TAS blood coagulation
GO:0008286 TAS insulin receptor signaling pathway
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0010518 IMP positive regulation of phospholipase activity
GO:0010594 IEA regulation of endothelial cell migration
GO:0010667 IEA negative regulation of cardiac muscle cell apoptotic process
GO:0016004 IMP phospholipase activator activity
GO:0016023 IEA cytoplasmic membrane-bounded vesicle
GO:0016301 EXP kinase activity
GO:0016477 IMP cell migration
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018107 IDA peptidyl-threonine phosphorylation
GO:0019722 IMP calcium-mediated signaling
GO:0019901 IEA protein kinase binding
GO:0030036 TAS actin cytoskeleton organization
GO:0030054 IEA cell junction
GO:0030168 TAS platelet activation
GO:0030512 IDA negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031295 TAS T cell costimulation
GO:0032148 IDA activation of protein kinase B activity
GO:0032869 IMP cellular response to insulin stimulus
GO:0034122 IEA negative regulation of toll-like receptor signaling pathway
GO:0035556 IDA intracellular signal transduction
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042995 IDA cell projection
GO:0043122 IMP regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043274 IPI phospholipase binding
GO:0043304 IEA regulation of mast cell degranulation
GO:0045087 TAS innate immune response
GO:0046777 TAS protein autophosphorylation
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0048041 IEA focal adhesion assembly
GO:0050852 TAS T cell receptor signaling pathway
GO:0051281 IDA positive regulation of release of sequestered calcium ion into cytosol
GO:0071364 IMP cellular response to epidermal growth factor stimulus
GO:0090004 IMP positive regulation of establishment of protein localization to plasma membrane
GO:0097191 IMP extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000018285 pdpk1b 3-phosphoinositide dependent protein kinase-1b protein_coding Danio_rerio
ENSDARG00000062304 pdpk1a 3-phosphoinositide dependent protein kinase-1a protein_coding Danio_rerio
ENSMUSG00000024122 Pdpk1 3-phosphoinositide dependent protein kinase 1 protein_coding Mus_musculus

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