C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: 3-phosphoinositide dependent protein kinase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000024122 Pdpk1 10090 - 17:24073680-24150924 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000052462 Pdpk1-004 24078928-24150924 protein_coding
  ENSMUST00000102927 Pdpk1-001 24073680-24141595 protein_coding
  ENSMUST00000115407 Pdpk1-006 24078881-24141576 protein_coding
  ENSMUST00000115409 Pdpk1-007 24075812-24141570 protein_coding
  ENSMUST00000115411 Pdpk1-003 24073683-24141553 protein_coding
  ENSMUST00000128997 Pdpk1-008 24110892-24141128 protein_coding
  ENSMUST00000140906 Pdpk1-005 24091584-24150916 processed_transcript
  ENSMUST00000144533 Pdpk1-009 24106835-24140807 protein_coding
  ENSMUST00000147199 Pdpk1-011 24088181-24093798 processed_transcript
  ENSMUST00000150578 Pdpk1-002 24104010-24141556 retained_intron
  ENSMUST00000154982 Pdpk1-010 24106887-24120794 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000052462ENSMUST00000102927ENSMUST00000115407ENSMUST00000115409ENSMUST00000140906
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000052462 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 60.945±23.56
ENSMUST00000102927 8.090±1.22 5.636±1.01 8.201±1.34 12.783±9.73 5.798±1.20 6.822±1.35 4.857±0.58 6.605±0.55 6.178±3.34 6.677±2.85 3.711±1.21 5.927±2.87 6.453±2.83 7.495±0.09
ENSMUST00000115407 N/A 11.864±3.53 N/A N/A 7.186±1.17 5.816±1.93 N/A N/A N/A 4.807±0.00 N/A 6.917±1.25 N/A N/A
ENSMUST00000115409 3.555±0.23 11.001±3.27 N/A N/A 7.379±0.75 5.563±1.73 1.887±0.04 3.369±1.45 1.965±0.58 4.499±0.31 N/A 7.025±1.97 N/A 1.571±0.00
ENSMUST00000140906 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 177.042±16.88

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005ER CIL_0005ER_0002 CGP 17:24047734-24150924

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003323 IMP type B pancreatic cell development
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004676 IDA 3-phosphoinositide-dependent protein kinase activity
GO:0005158 IEA insulin receptor binding
GO:0005515 IEA protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 IEA cytosol
GO:0005886 IEA plasma membrane
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006468 IEA protein phosphorylation
GO:0006469 IEA negative regulation of protein kinase activity
GO:0006972 IDA hyperosmotic response
GO:0007165 TAS signal transduction
GO:0007173 IEA epidermal growth factor receptor signaling pathway
GO:0010518 IEA positive regulation of phospholipase activity
GO:0010594 IMP regulation of endothelial cell migration
GO:0010667 IMP negative regulation of cardiac muscle cell apoptotic process
GO:0016004 IEA phospholipase activator activity
GO:0016023 IDA cytoplasmic membrane-bounded vesicle
GO:0016301 IEA kinase activity
GO:0016477 IEA cell migration
GO:0018107 IEA peptidyl-threonine phosphorylation
GO:0019722 IEA calcium-mediated signaling
GO:0019901 IEA protein kinase binding
GO:0030054 IEA cell junction
GO:0030512 IEA negative regulation of transforming growth factor beta receptor signaling pathway
GO:0032148 IEA activation of protein kinase B activity
GO:0032869 IEA cellular response to insulin stimulus
GO:0034122 IMP negative regulation of toll-like receptor signaling pathway
GO:0035556 IEA intracellular signal transduction
GO:0042995 IEA cell projection
GO:0043122 IEA regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043274 IEA phospholipase binding
GO:0043304 IMP regulation of mast cell degranulation
GO:0048041 IEA focal adhesion assembly
GO:0051281 IEA positive regulation of release of sequestered calcium ion into cytosol
GO:0071364 IEA cellular response to epidermal growth factor stimulus
GO:0090004 IEA positive regulation of establishment of protein localization to plasma membrane
GO:0097191 IEA extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000018285 pdpk1b 3-phosphoinositide dependent protein kinase-1b protein_coding Danio_rerio
ENSDARG00000062304 pdpk1a 3-phosphoinositide dependent protein kinase-1a protein_coding Danio_rerio
ENSG00000140992 PDPK1 3-phosphoinositide dependent protein kinase 1 protein_coding Homo_sapiens

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