C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: 3-phosphoinositide dependent protein kinase 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000342085 PDPK1-001 ENSG00000140992 9606 + 16:2537964-2603188 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBrainBreastColonHeartKidneyLiverOvaryPlacentaTestisENST00000342085
Transcript ID Adrenal Brain Breast Colon Heart Kidney Liver Ovary Placenta Testis
ENST00000342085 2.861±0.00 5.575±1.66 2.026±0.00 1.093±0.37 4.911±0.00 0.368±0.00 3.670±0.00 2.934±1.86 6.589±3.27 16.018±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0003323 IEA type B pancreatic cell development
GO:0004672 IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004676 IDA 3-phosphoinositide-dependent protein kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005158 IEA insulin receptor binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006468 IEA:IDA protein phosphorylation
GO:0006469 IDA negative regulation of protein kinase activity
GO:0006972 IEA hyperosmotic response
GO:0007173 IMP epidermal growth factor receptor signaling pathway
GO:0007268 TAS synaptic transmission
GO:0007596 TAS blood coagulation
GO:0008286 TAS insulin receptor signaling pathway
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0010518 IMP positive regulation of phospholipase activity
GO:0010594 IEA regulation of endothelial cell migration
GO:0010667 IEA negative regulation of cardiac muscle cell apoptotic process
GO:0016004 IMP phospholipase activator activity
GO:0016023 IEA cytoplasmic membrane-bounded vesicle
GO:0016301 EXP kinase activity
GO:0016477 IMP cell migration
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018107 IDA peptidyl-threonine phosphorylation
GO:0019722 IMP calcium-mediated signaling
GO:0019901 IEA protein kinase binding
GO:0030036 TAS actin cytoskeleton organization
GO:0030054 IEA cell junction
GO:0030168 TAS platelet activation
GO:0030512 IDA negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031295 TAS T cell costimulation
GO:0032148 IDA activation of protein kinase B activity
GO:0032869 IMP cellular response to insulin stimulus
GO:0034122 IEA negative regulation of toll-like receptor signaling pathway
GO:0035556 IDA intracellular signal transduction
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042995 IDA cell projection
GO:0043122 IMP regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043274 IPI phospholipase binding
GO:0043304 IEA regulation of mast cell degranulation
GO:0045087 TAS innate immune response
GO:0046777 TAS protein autophosphorylation
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0048041 IEA focal adhesion assembly
GO:0050852 TAS T cell receptor signaling pathway
GO:0051281 IDA positive regulation of release of sequestered calcium ion into cytosol
GO:0071364 IMP cellular response to epidermal growth factor stimulus
GO:0090004 IMP positive regulation of establishment of protein localization to plasma membrane
GO:0097191 IMP extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000102927 Pdpk1-001 protein_coding Mus_musculus 0 2505
ENSMUST00000052462 Pdpk1-004 protein_coding Mus_musculus 0 2078
ENSMUST00000115411 Pdpk1-003 protein_coding Mus_musculus 0 1975
ENSMUST00000115407 Pdpk1-006 protein_coding Mus_musculus 0 1722
ENSMUST00000115409 Pdpk1-007 protein_coding Mus_musculus 0 1467
ENSMUST00000140906 Pdpk1-005 processed_transcript Mus_musculus 0 481
ENSMUST00000150578 Pdpk1-002 retained_intron Mus_musculus 0 444
ENSMUST00000144533 Pdpk1-009 protein_coding Mus_musculus 0 416
ENSMUST00000154982 Pdpk1-010 protein_coding Mus_musculus 0 340
ENSMUST00000128997 Pdpk1-008 protein_coding Mus_musculus 4e-35 156
ENSDART00000003789 pdpk1b-001 protein_coding Danio_rerio 5e-34 152

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