C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: phosphofructokinase, liver
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000141959 PFKL 9606 + 21:44300051-44327376 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000349048 PFKL-001 44300051-44327376 protein_coding
  ENST00000397961 PFKL-002 44300051-44327376 nonsense_mediated_decay
  ENST00000460020 PFKL-010 44319841-44324543 retained_intron
  ENST00000460521 PFKL-007 44320577-44327376 retained_intron
  ENST00000466134 PFKL-003 44300096-44327376 retained_intron
  ENST00000467315 PFKL-006 44319867-44327376 retained_intron
  ENST00000474114 PFKL-004 44315527-44327376 retained_intron
  ENST00000491298 PFKL-009 44305194-44313954 processed_transcript
  ENST00000495274 PFKL-011 44322962-44325635 retained_intron
  ENST00000496824 PFKL-008 44300067-44316339 processed_transcript
  ENST00000498841 PFKL-005 44319623-44327376 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000349048ENST00000466134ENST00000467315ENST00000491298ENST00000495274
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000349048 75.104±0.00 48.789±0.00 9.238±0.00 33.873±26.10 32.274±21.51 28.887±18.07 7.725±6.23 48.899±33.77 13.755±8.99 23.473±17.25 5.307±0.00 53.183±27.97 93.745±8.78 51.328±1.45
ENST00000466134 N/A N/A N/A N/A N/A N/A 0.173±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000467315 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.580±0.00 N/A N/A N/A
ENST00000491298 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.231±0.00 N/A N/A N/A
ENST00000495274 N/A N/A 9.401±0.00 N/A N/A N/A 1.200±0.00 N/A N/A N/A 2.955±0.00 N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003872 IDA:IEA 6-phosphofructokinase activity
GO:0005515 IPI protein binding
GO:0005524 IDA:IEA ATP binding
GO:0005737 IEA cytoplasm
GO:0005829 IDA cytosol
GO:0005945 IDA 6-phosphofructokinase complex
GO:0005975 TAS carbohydrate metabolic process
GO:0006002 IMP fructose 6-phosphate metabolic process
GO:0006006 TAS glucose metabolic process
GO:0006096 IEA glycolytic process
GO:0009749 IDA response to glucose
GO:0016020 IDA membrane
GO:0019900 IPI kinase binding
GO:0030388 IDA fructose 1,6-bisphosphate metabolic process
GO:0042802 IPI identical protein binding
GO:0044281 TAS small molecule metabolic process
GO:0046676 IEA negative regulation of insulin secretion
GO:0046835 IEA carbohydrate phosphorylation
GO:0046872 IEA metal ion binding
GO:0048029 IEA monosaccharide binding
GO:0051259 IDA protein oligomerization
GO:0051289 IEA protein homotetramerization
GO:0070061 IDA fructose binding
GO:0070062 IDA extracellular vesicular exosome
GO:0070095 IDA fructose-6-phosphate binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000042375 pfklb phosphofructokinase, liver b protein_coding Danio_rerio
ENSDARG00000060504 PFKL (2 of 2) phosphofructokinase, liver protein_coding Danio_rerio
ENSMUSG00000020277 Pfkl phosphofructokinase, liver, B-type protein_coding Mus_musculus

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