C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: protein kinase, cAMP-dependent, catalytic, beta
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000142875 PRKACB 9606 + 1:84078062-84238498 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000370680 PRKACB-003 84164695-84205297 protein_coding
  ENST00000370682 PRKACB-201 84164382-84238494 protein_coding
  ENST00000370684 PRKACB-008 84164317-84204525 protein_coding
  ENST00000370685 PRKACB-004 84144271-84238498 protein_coding
  ENST00000370688 PRKACB-002 84078144-84205439 protein_coding
  ENST00000370689 PRKACB-001 84078062-84238498 protein_coding
  ENST00000394838 PRKACB-202 84164382-84238494 protein_coding
  ENST00000394839 PRKACB-005 84164966-84238498 protein_coding
  ENST00000413538 PRKACB-012 84164904-84197824 protein_coding
  ENST00000417530 PRKACB-013 84164912-84197812 protein_coding
  ENST00000432111 PRKACB-010 84164394-84202695 protein_coding
  ENST00000436133 PRKACB-009 84164323-84196742 protein_coding
  ENST00000446538 PRKACB-007 84164302-84196702 protein_coding
  ENST00000450730 PRKACB-011 84164681-84197791 protein_coding
  ENST00000467507 PRKACB-014 84178835-84184046 processed_transcript
  ENST00000470673 PRKACB-006 84144322-84196696 processed_transcript
  ENST00000610457 PRKACB-203 84181660-84238494 protein_coding
  ENST00000610703 PRKACB-204 84164382-84238494 protein_coding
  ENST00000614872 PRKACB-205 84164966-84238496 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000370682ENST00000370685ENST00000370688ENST00000370689ENST00000432111ENST00000610457ENST00000610703ENST00000614872
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000370682 N/A N/A N/A 15.081±2.67 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000370685 0.799±0.00 0.953±0.00 1.782±0.00 N/A 4.425±2.88 11.421±0.00 0.575±0.00 1.660±0.80 5.351±0.00 5.103±4.29 N/A 0.995±0.70 0.728±0.10 N/A
ENST00000370688 N/A 1.592±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.293±0.00 N/A 1.197±0.00
ENST00000370689 3.465±0.00 3.563±0.00 2.062±0.00 42.623±0.00 4.331±0.00 10.892±0.00 3.624±2.45 3.262±2.20 3.876±1.49 2.448±0.00 1.939±0.00 3.380±2.22 1.354±0.29 4.499±2.73
ENST00000432111 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.764±0.00 4.596±0.00 3.682±0.00
ENST00000610457 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.435±0.03 1.934±0.00 N/A N/A
ENST00000610703 N/A 1.319±0.00 N/A 15.448±0.00 N/A N/A N/A 1.575±0.00 N/A N/A N/A N/A 1.739±0.65 N/A
ENST00000614872 N/A N/A N/A 16.737±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000287 IDA magnesium ion binding
GO:0001843 IEA neural tube closure
GO:0004672 IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004691 IDA cAMP-dependent protein kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IEA cytoplasm
GO:0005813 IDA centrosome
GO:0005829 TAS cytosol
GO:0005886 IEA plasma membrane
GO:0005952 TAS cAMP-dependent protein kinase complex
GO:0005975 TAS carbohydrate metabolic process
GO:0006006 TAS glucose metabolic process
GO:0006094 TAS gluconeogenesis
GO:0006112 TAS energy reserve metabolic process
GO:0006468 IEA protein phosphorylation
GO:0006833 TAS water transport
GO:0007165 TAS signal transduction
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007188 TAS adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007202 TAS activation of phospholipase C activity
GO:0007268 TAS synaptic transmission
GO:0007596 TAS blood coagulation
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0019433 TAS triglyceride catabolic process
GO:0031625 IDA ubiquitin protein ligase binding
GO:0034199 TAS activation of protein kinase A activity
GO:0035556 TAS intracellular signal transduction
GO:0044281 TAS small molecule metabolic process
GO:0045087 TAS innate immune response
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048471 IEA perinuclear region of cytoplasm
GO:0050796 TAS regulation of insulin secretion
GO:0051447 IEA negative regulation of meiotic cell cycle
GO:0055085 TAS transmembrane transport
GO:0070062 IDA extracellular vesicular exosome
GO:0070613 IEA regulation of protein processing
GO:0071377 TAS cellular response to glucagon stimulus
GO:0097338 IEA response to clozapine
GO:0097546 IEA ciliary base
GO:1901621 IEA negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000059125 prkacbb protein kinase, cAMP-dependent, catalytic, beta b protein_coding Danio_rerio
ENSDARG00000087866 prkacbb protein kinase, cAMP-dependent, catalytic, beta b protein_coding Danio_rerio
ENSMUSG00000005034 Prkacb protein kinase, cAMP dependent, catalytic, beta protein_coding Mus_musculus

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