C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: angiotensin II receptor, type 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000144891 AGTR1 9606 + 3:148697784-148743008 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000349243 AGTR1-001 148697871-148743003 protein_coding
  ENST00000402260 AGTR1-201 148739798-148743001 protein_coding
  ENST00000404754 AGTR1-003 148697918-148743008 protein_coding
  ENST00000418473 AGTR1-202 148730180-148743001 protein_coding
  ENST00000461609 AGTR1-007 148730124-148742247 protein_coding
  ENST00000474935 AGTR1-006 148730100-148742247 protein_coding
  ENST00000475166 AGTR1-004 148698175-148731497 processed_transcript
  ENST00000475347 AGTR1-005 148730100-148742247 protein_coding
  ENST00000497524 AGTR1-002 148697784-148743003 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000349243ENST00000402260ENST00000404754ENST00000418473ENST00000461609ENST00000475166ENST00000475347ENST00000497524
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000349243 N/A N/A 0.471±0.00 N/A 1.292±0.33 0.554±0.00 0.504±0.00 3.346±0.07 2.133±0.00 0.202±0.00 N/A 0.246±0.00 11.437±4.08 N/A
ENST00000402260 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.389±0.00 N/A 0.355±0.00
ENST00000404754 29.547±0.00 1.502±0.00 N/A 0.089±0.00 7.510±0.00 14.773±0.00 1.513±0.00 5.533±0.00 15.027±0.00 1.155±0.00 3.145±0.00 0.395±0.00 28.119±14.76 3.490±3.26
ENST00000418473 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.055±0.00 14.261±0.00 N/A
ENST00000461609 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.047±0.00 N/A N/A
ENST00000475166 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.037±0.00 N/A N/A
ENST00000475347 N/A N/A N/A N/A N/A N/A N/A 2.218±0.00 N/A N/A N/A N/A N/A N/A
ENST00000497524 N/A N/A N/A N/A 0.748±0.00 0.557±0.00 0.433±0.12 3.258±0.00 1.146±0.00 1.052±0.83 0.710±0.15 0.515±0.33 14.218±0.00 N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001558 NAS regulation of cell growth
GO:0001596 IDA angiotensin type I receptor activity
GO:0001822 IMP kidney development
GO:0002018 NAS renin-angiotensin regulation of aldosterone production
GO:0002034 IC regulation of blood vessel size by renin-angiotensin
GO:0003081 IC regulation of systemic arterial blood pressure by renin-angiotensin
GO:0004930 IEA G-protein coupled receptor activity
GO:0004945 IDA angiotensin type II receptor activity
GO:0005515 IPI protein binding
GO:0005886 IDA plasma membrane
GO:0005887 IC integral component of plasma membrane
GO:0007186 IDA:IEA G-protein coupled receptor signaling pathway
GO:0007200 NAS phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204 IDA positive regulation of cytosolic calcium ion concentration
GO:0007266 IDA Rho protein signal transduction
GO:0010744 IC positive regulation of macrophage derived foam cell differentiation
GO:0010873 IMP positive regulation of cholesterol esterification
GO:0016021 NAS:IEA integral component of membrane
GO:0019229 IC regulation of vasoconstriction
GO:0019722 IDA calcium-mediated signaling
GO:0031711 IPI bradykinin receptor binding
GO:0032270 IMP positive regulation of cellular protein metabolic process
GO:0032430 IMP positive regulation of phospholipase A2 activity
GO:0033864 TAS positive regulation of NAD(P)H oxidase activity
GO:0034374 NAS low-density lipoprotein particle remodeling
GO:0035813 NAS regulation of renal sodium excretion
GO:0038166 IDA angiotensin-activated signaling pathway
GO:0042127 NAS regulation of cell proliferation
GO:0042312 IC regulation of vasodilation
GO:0046982 IPI protein heterodimerization activity
GO:0050727 IC regulation of inflammatory response
GO:0050729 TAS positive regulation of inflammatory response
GO:0051482 IDA positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0060326 IDA cell chemotaxis
GO:0086097 IDA phospholipase C-activating angiotensin-activated signaling pathway
GO:2000379 TAS positive regulation of reactive oxygen species metabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000018616 agtr1a angiotensin II receptor, type 1a protein_coding Danio_rerio
ENSDARG00000045443 agtr1b angiotensin II receptor, type 1b protein_coding Danio_rerio
ENSMUSG00000049115 Agtr1a angiotensin II receptor, type 1a protein_coding Mus_musculus
ENSMUSG00000054988 Agtr1b angiotensin II receptor, type 1b protein_coding Mus_musculus

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