C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: angiotensin II receptor, type 1a
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000049115 Agtr1a 10090 + 13:30336441-30382867 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000066412 Agtr1a-001 30336441-30382867 protein_coding
  ENSMUST00000143181 Agtr1a-002 30336441-30345910 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000066412ENSMUST00000143181
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000066412 11.891±1.14 108.581±3.88 2.892±0.38 0.268±0.17 20.591±3.79 4.708±0.79 20.590±3.75 41.357±6.47 35.752±23.84 13.756±0.95 1.024±0.20 3.540±1.62 2.604±3.04 13.290±7.46
ENSMUST00000143181 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.322±0.00 N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001568 IGI blood vessel development
GO:0001596 IDA angiotensin type I receptor activity
GO:0001822 IMP kidney development
GO:0001921 IEA positive regulation of receptor recycling
GO:0001965 IEA G-protein alpha-subunit binding
GO:0001991 IGI regulation of systemic arterial blood pressure by circulatory renin-angiotensin
GO:0002001 IMP renin secretion into blood stream
GO:0002018 IMP renin-angiotensin regulation of aldosterone production
GO:0002019 IMP regulation of renal output by angiotensin
GO:0002035 IMP brain renin-angiotensin system
GO:0004945 IEA angiotensin type II receptor activity
GO:0005515 IPI protein binding
GO:0005737 IDA cytoplasm
GO:0005768 IDA endosome
GO:0005794 IEA Golgi apparatus
GO:0005886 IDA plasma membrane
GO:0006885 IEA regulation of pH
GO:0006954 IGI inflammatory response
GO:0007186 IC G-protein coupled receptor signaling pathway
GO:0007200 IEA phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204 IEA positive regulation of cytosolic calcium ion concentration
GO:0007507 IMP heart development
GO:0007568 IEA aging
GO:0008284 IMP positive regulation of cell proliferation
GO:0012505 IEA endomembrane system
GO:0012506 IEA vesicle membrane
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0016323 IEA basolateral plasma membrane
GO:0017046 IEA peptide hormone binding
GO:0019229 IEA regulation of vasoconstriction
GO:0019901 IEA protein kinase binding
GO:0030425 IEA dendrite
GO:0031410 IEA cytoplasmic vesicle
GO:0031748 IEA D1 dopamine receptor binding
GO:0031968 IEA organelle outer membrane
GO:0031983 IEA vesicle lumen
GO:0032930 IEA positive regulation of superoxide anion generation
GO:0034391 IGI regulation of smooth muscle cell apoptotic process
GO:0034392 IMP negative regulation of smooth muscle cell apoptotic process
GO:0042310 IEA vasoconstriction
GO:0042416 IEA dopamine biosynthetic process
GO:0042756 IGI drinking behavior
GO:0042976 IEA activation of Janus kinase activity
GO:0043621 IEA protein self-association
GO:0043627 IEA response to estrogen
GO:0045777 IDA positive regulation of blood pressure
GO:0050715 IMP positive regulation of cytokine secretion
GO:0055037 IEA recycling endosome
GO:0071549 IEA cellular response to dexamethasone stimulus
GO:0086097 IEA phospholipase C-activating angiotensin-activated signaling pathway
GO:0090190 IEA positive regulation of branching involved in ureteric bud morphogenesis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000018616 agtr1a angiotensin II receptor, type 1a protein_coding Danio_rerio
ENSDARG00000045443 agtr1b angiotensin II receptor, type 1b protein_coding Danio_rerio
ENSG00000144891 AGTR1 angiotensin II receptor, type 1 protein_coding Homo_sapiens

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