C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ankyrin 2, neuronal
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000145362 ANK2 9606 + 4:112818109-113383740 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000264366 ANK2-026 113049729-113381471 protein_coding
  ENST00000357077 ANK2-001 113049676-113383740 protein_coding
  ENST00000394537 ANK2-002 113049676-113382112 protein_coding
  ENST00000502701 ANK2-025 113293360-113318606 retained_intron
  ENST00000503271 ANK2-009 112818109-113335871 protein_coding
  ENST00000503423 ANK2-010 112818109-113353713 protein_coding
  ENST00000504415 ANK2-022 113341712-113363440 protein_coding
  ENST00000504454 ANK2-005 113049650-113353764 protein_coding
  ENST00000504887 ANK2-018 113336344-113341818 processed_transcript
  ENST00000505342 ANK2-011 113357589-113383740 protein_coding
  ENST00000506344 ANK2-023 113373317-113381943 protein_coding
  ENST00000506722 ANK2-004 112818109-113383735 protein_coding
  ENST00000508007 ANK2-019 113347796-113365136 retained_intron
  ENST00000508613 ANK2-013 113116993-113236990 protein_coding
  ENST00000509550 ANK2-006 113292982-113381647 protein_coding
  ENST00000510275 ANK2-008 113341833-113381567 protein_coding
  ENST00000511380 ANK2-014 113145632-113196466 protein_coding
  ENST00000512298 ANK2-020 113348258-113350811 retained_intron
  ENST00000512999 ANK2-021 113141249-113151208 processed_transcript
  ENST00000514160 ANK2-017 113332982-113336593 retained_intron
  ENST00000514167 ANK2-024 113373359-113381516 protein_coding
  ENST00000514246 ANK2-012 113049656-113070150 processed_transcript
  ENST00000514960 ANK2-007 113318585-113383732 protein_coding
  ENST00000515034 ANK2-015 113174018-113237105 protein_coding
  ENST00000515644 ANK2-016 113317452-113330363 retained_intron
  ENST00000612754 ANK2-201 113355717-113383729 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000264366ENST00000357077ENST00000394537ENST00000505342ENST00000506722ENST00000509550ENST00000510275ENST00000514960ENST00000612754
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000264366 N/A N/A 3.536±0.00 11.939±0.00 N/A N/A N/A N/A N/A 0.269±0.00 N/A N/A N/A 0.597±0.00
ENST00000357077 N/A N/A N/A 8.337±0.03 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000394537 N/A N/A 5.568±0.00 15.060±0.00 N/A 1.923±0.00 N/A N/A 2.761±0.00 N/A 1.836±0.00 2.987±0.70 N/A N/A
ENST00000505342 N/A N/A N/A 18.517±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 0.052±0.00 N/A
ENST00000506722 N/A 1.055±0.00 N/A 19.290±4.27 N/A N/A N/A N/A N/A N/A 1.109±0.00 N/A N/A N/A
ENST00000509550 N/A N/A N/A N/A 3.442±0.00 N/A N/A N/A N/A 1.149±0.00 N/A N/A N/A N/A
ENST00000510275 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.718±0.00 2.871±0.00
ENST00000514960 9.297±0.00 5.141±0.00 8.459±0.00 21.283±0.00 5.184±0.44 6.850±4.67 8.748±1.75 4.761±4.69 5.584±0.00 1.433±0.22 2.607±0.09 4.788±3.46 0.386±0.34 7.713±0.00
ENST00000612754 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.087±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008WR CIL_0008WR_0001 VISTA 4:112221234-112822374
CIL_0006YO CIL_0006YO_0002 CGP 4:112818109-113761927

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002027 IMP regulation of heart rate
GO:0003283 IMP atrial septum development
GO:0005200 IEA structural constituent of cytoskeleton
GO:0005515 IEA protein binding
GO:0005622 IGI intracellular
GO:0005737 IEA cytoplasm
GO:0005829 TAS cytosol
GO:0005856 IEA cytoskeleton
GO:0005886 ISS plasma membrane
GO:0005887 IEA integral component of plasma membrane
GO:0006874 ISS cellular calcium ion homeostasis
GO:0007165 IEA signal transduction
GO:0007399 IEA nervous system development
GO:0007411 TAS axon guidance
GO:0008104 IEA protein localization
GO:0010628 IGI positive regulation of gene expression
GO:0010881 IGI regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0010882 IMP regulation of cardiac muscle contraction by calcium ion signaling
GO:0014704 ISS intercalated disc
GO:0015459 IEA potassium channel regulator activity
GO:0016323 IDA basolateral plasma membrane
GO:0019899 IPI enzyme binding
GO:0019901 IPI protein kinase binding
GO:0030018 ISS Z disc
GO:0030315 ISS T-tubule
GO:0030507 IPI spectrin binding
GO:0030674 ISS protein binding, bridging
GO:0030913 IEA paranodal junction assembly
GO:0031430 ISS M band
GO:0031647 IC regulation of protein stability
GO:0031672 ISS A band
GO:0033292 ISS T-tubule organization
GO:0033365 IGI protein localization to organelle
GO:0034394 ISS protein localization to cell surface
GO:0034613 IGI cellular protein localization
GO:0036309 ISS protein localization to M-band
GO:0036371 ISS protein localization to T-tubule
GO:0042383 ISS sarcolemma
GO:0043005 IEA neuron projection
GO:0043034 ISS costamere
GO:0043268 ISS positive regulation of potassium ion transport
GO:0044325 ISS ion channel binding
GO:0045121 IEA membrane raft
GO:0045211 IEA postsynaptic membrane
GO:0048471 IEA perinuclear region of cytoplasm
GO:0050821 ISS protein stabilization
GO:0051117 ISS ATPase binding
GO:0051279 IGI regulation of release of sequestered calcium ion into cytosol
GO:0051597 IEA response to methylmercury
GO:0051924 IGI regulation of calcium ion transport
GO:0051928 ISS positive regulation of calcium ion transport
GO:0055117 IMP regulation of cardiac muscle contraction
GO:0060048 IEA cardiac muscle contraction
GO:0060307 IMP regulation of ventricular cardiac muscle cell membrane repolarization
GO:0070296 TAS sarcoplasmic reticulum calcium ion transport
GO:0070972 IGI protein localization to endoplasmic reticulum
GO:0072659 ISS protein localization to plasma membrane
GO:0072661 IEA protein targeting to plasma membrane
GO:0086004 IGI regulation of cardiac muscle cell contraction
GO:0086005 IMP ventricular cardiac muscle cell action potential
GO:0086014 IMP atrial cardiac muscle cell action potential
GO:0086015 ISS SA node cell action potential
GO:0086036 IEA regulation of cardiac muscle cell membrane potential
GO:0086046 TAS membrane depolarization during SA node cell action potential
GO:0086066 ISS atrial cardiac muscle cell to AV node cell communication
GO:0086070 IMP SA node cell to atrial cardiac muscle cell communication
GO:0086091 ISS regulation of heart rate by cardiac conduction
GO:1901018 ISS positive regulation of potassium ion transmembrane transporter activity
GO:1901019 ISS regulation of calcium ion transmembrane transporter activity
GO:1901021 ISS positive regulation of calcium ion transmembrane transporter activity
GO:2001257 IEA regulation of cation channel activity
GO:2001259 ISS positive regulation of cation channel activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000009026 CR388002.1 Uncharacterized protein protein_coding Danio_rerio
ENSDARG00000043313 ank2b ankyrin 2b, neuronal protein_coding Danio_rerio
ENSMUSG00000032826 Ank2 ankyrin 2, brain protein_coding Mus_musculus

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