C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: polo-like kinase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000145632 PLK2 9606 - 5:58453982-58460260 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000274289 PLK2-001 58453982-58460260 protein_coding
  ENST00000502671 PLK2-012 58453985-58457569 processed_transcript
  ENST00000503115 PLK2-010 58457006-58457737 retained_intron
  ENST00000503378 PLK2-015 58454975-58456194 retained_intron
  ENST00000503713 PLK2-013 58456147-58457279 retained_intron
  ENST00000504196 PLK2-006 58458865-58460086 retained_intron
  ENST00000505244 PLK2-014 58455611-58456413 retained_intron
  ENST00000508300 PLK2-005 58457516-58459139 retained_intron
  ENST00000509422 PLK2-008 58457494-58458573 retained_intron
  ENST00000509555 PLK2-009 58457309-58458895 retained_intron
  ENST00000510629 PLK2-011 58456743-58457421 retained_intron
  ENST00000511326 PLK2-016 58454706-58455116 retained_intron
  ENST00000514306 PLK2-007 58458297-58459859 retained_intron
  ENST00000515415 PLK2-004 58457061-58459505 retained_intron
  ENST00000617412 PLK2-201 58453987-58460139 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000274289ENST00000502671ENST00000503378ENST00000508300ENST00000617412
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000274289 1.387±0.00 2.948±0.00 N/A 12.203±2.46 6.160±0.22 1.771±0.11 3.300±0.08 N/A 2.281±1.12 8.670±2.45 N/A 5.711±3.20 13.585±1.57 14.794±5.48
ENST00000502671 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.386±0.00 N/A N/A N/A
ENST00000503378 N/A 11.189±0.00 N/A N/A N/A N/A N/A 2.707±0.00 N/A N/A 3.565±1.59 N/A N/A N/A
ENST00000508300 N/A N/A N/A N/A N/A 2.222±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000617412 0.766±0.00 4.310±0.00 0.919±0.00 5.999±2.97 12.139±0.00 1.819±0.00 8.884±0.00 1.865±0.81 1.434±0.00 6.844±0.91 0.521±0.00 2.262±0.61 14.189±0.00 8.244±1.40

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 IMP G1/S transition of mitotic cell cycle
GO:0000278 IEA mitotic cell cycle
GO:0004672 IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0004871 IMP signal transducer activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005622 ISS intracellular
GO:0005813 IDA centrosome
GO:0005814 IDA centriole
GO:0006468 IDA:IEA protein phosphorylation
GO:0007052 IDA mitotic spindle organization
GO:0007093 ISS mitotic cell cycle checkpoint
GO:0007265 ISS Ras protein signal transduction
GO:0007613 ISS memory
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0030425 ISS dendrite
GO:0032092 IEA positive regulation of protein binding
GO:0032403 IEA protein complex binding
GO:0032436 IEA positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032486 ISS Rap protein signal transduction
GO:0043066 ISS negative regulation of apoptotic process
GO:0043123 IMP positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0046599 IMP regulation of centriole replication
GO:0048167 ISS regulation of synaptic plasticity
GO:0060291 ISS long-term synaptic potentiation
GO:0060292 ISS long term synaptic depression
GO:0061000 IEA negative regulation of dendritic spine development

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000090752 plk2a polo-like kinase 2a (Drosophila) protein_coding Danio_rerio
ENSMUSG00000021701 Plk2 polo-like kinase 2 protein_coding Mus_musculus

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