C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: peptidylglycine alpha-amidating monooxygenase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000145730 PAM 9606 + 5:102753981-103031105 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000304400 PAM-029 102866010-103029110 protein_coding
  ENST00000345721 PAM-006 102865819-103029511 nonsense_mediated_decay
  ENST00000346918 PAM-003 102865737-103029244 protein_coding
  ENST00000348126 PAM-001 102865823-103029713 protein_coding
  ENST00000379799 PAM-005 102949577-103029594 protein_coding
  ENST00000438793 PAM-004 102865726-103031105 protein_coding
  ENST00000455264 PAM-002 102866116-103029165 protein_coding
  ENST00000502472 PAM-009 102808057-102946885 processed_transcript
  ENST00000504456 PAM-027 103007569-103029192 processed_transcript
  ENST00000504691 PAM-008 103007559-103029730 protein_coding
  ENST00000505372 PAM-024 102959997-102974837 retained_intron
  ENST00000505654 PAM-012 102753981-102866282 protein_coding
  ENST00000506006 PAM-018 102865310-102866280 protein_coding
  ENST00000506127 PAM-011 102755314-102838589 processed_transcript
  ENST00000506260 PAM-022 102895913-102949573 processed_transcript
  ENST00000508060 PAM-013 102754667-102865912 processed_transcript
  ENST00000509523 PAM-015 102808063-102866192 processed_transcript
  ENST00000509636 PAM-020 102866587-102946876 processed_transcript
  ENST00000509832 PAM-019 102865479-102867342 protein_coding
  ENST00000510006 PAM-028 103007453-103029267 processed_transcript
  ENST00000510208 PAM-014 102754783-102866080 processed_transcript
  ENST00000511429 PAM-023 102989771-103006859 retained_intron
  ENST00000511477 PAM-017 102865244-102867309 protein_coding
  ENST00000511839 PAM-016 102864537-102867388 protein_coding
  ENST00000512073 PAM-010 102755343-102866270 protein_coding
  ENST00000513648 PAM-021 102865819-102873804 processed_transcript
  ENST00000515456 PAM-026 103007542-103028222 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000304400ENST00000345721ENST00000348126ENST00000379799ENST00000455264ENST00000504691
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000304400 4.968±0.00 N/A 1.884±0.00 4.876±0.00 N/A 5.830±0.00 43.814±23.41 0.423±0.00 13.880±0.00 6.360±0.00 6.185±2.35 6.441±0.73 13.513±0.00 2.392±0.00
ENST00000345721 N/A N/A N/A N/A N/A N/A 49.517±0.00 N/A N/A N/A 3.067±0.00 N/A N/A N/A
ENST00000348126 10.302±0.00 8.128±0.00 2.952±0.00 7.692±0.00 14.424±10.69 20.901±0.00 45.421±0.00 17.848±0.00 3.027±1.80 13.565±9.95 N/A 14.722±6.67 26.127±6.73 7.500±3.15
ENST00000379799 9.978±0.00 16.109±0.00 2.514±0.00 8.488±3.09 17.851±12.11 14.830±11.02 46.406±35.16 6.782±5.16 3.708±2.46 12.686±8.96 8.716±6.25 11.825±5.87 9.189±1.92 12.036±9.46
ENST00000455264 N/A N/A 2.722±0.00 5.694±0.00 4.496±0.00 3.337±0.00 11.325±0.00 N/A 6.644±0.00 N/A 4.015±0.00 7.330±0.00 N/A N/A
ENST00000504691 8.907±0.00 14.385±0.00 N/A N/A N/A N/A N/A 12.583±0.00 1.357±0.00 N/A 15.732±0.00 26.947±1.37 16.975±0.00 20.316±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007WC CIL_0007WC_0001 VISTA 5:102363369-102968199

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001519 IDA peptide amidation
GO:0003824 IEA catalytic activity
GO:0004497 IEA monooxygenase activity
GO:0004504 IDA peptidylglycine monooxygenase activity
GO:0004598 IDA peptidylamidoglycolate lyase activity
GO:0005507 IEA copper ion binding
GO:0005515 IPI:IEA protein binding
GO:0008270 IDA zinc ion binding
GO:0016020 IDA membrane
GO:0016021 IEA integral component of membrane
GO:0016715 IEA oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
GO:0031418 IEA L-ascorbic acid binding
GO:0055114 IEA oxidation-reduction process
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000042071 pam peptidylglycine alpha-amidating monooxygenase protein_coding Danio_rerio
ENSMUSG00000026335 Pam peptidylglycine alpha-amidating monooxygenase protein_coding Mus_musculus

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