C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: tousled-like kinase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000146872 TLK2 9606 + 17:62458658-62615481 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000326270 TLK2-004 62479025-62613490 protein_coding
  ENST00000343388 TLK2-002 62479150-62613489 protein_coding
  ENST00000346027 TLK2-001 62479025-62613490 protein_coding
  ENST00000542523 TLK2-201 62480768-62615478 protein_coding
  ENST00000577616 TLK2-009 62470959-62508511 processed_transcript
  ENST00000578697 TLK2-013 62552305-62576744 protein_coding
  ENST00000578931 TLK2-017 62600278-62606188 processed_transcript
  ENST00000579450 TLK2-008 62470942-62522268 protein_coding
  ENST00000580203 TLK2-006 62611946-62615481 retained_intron
  ENST00000580705 TLK2-012 62478066-62560034 protein_coding
  ENST00000581041 TLK2-005 62481121-62606241 protein_coding
  ENST00000581286 TLK2-014 62553444-62560309 retained_intron
  ENST00000582195 TLK2-010 62477839-62523177 protein_coding
  ENST00000582660 TLK2-016 62585596-62600767 retained_intron
  ENST00000582809 TLK2-003 62458658-62613664 protein_coding
  ENST00000583310 TLK2-018 62606096-62612573 retained_intron
  ENST00000583690 TLK2-011 62479246-62523141 nonsense_mediated_decay
  ENST00000583843 TLK2-007 62470933-62552339 protein_coding
  ENST00000584367 TLK2-015 62572847-62576728 retained_intron
  ENST00000619310 TLK2-202 62479025-62615478 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000326270ENST00000343388ENST00000346027ENST00000542523ENST00000578697ENST00000580203ENST00000580705ENST00000581041ENST00000581286ENST00000582809ENST00000619310
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000326270 N/A N/A 2.419±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 7.886±0.00
ENST00000343388 N/A 1.067±0.00 N/A N/A 1.616±0.38 2.548±0.00 N/A 1.407±0.00 N/A N/A 0.894±0.00 3.107±0.00 2.607±0.26 4.411±0.00
ENST00000346027 1.586±0.00 N/A N/A 3.032±0.00 N/A N/A 1.779±0.09 0.893±0.10 0.528±0.00 2.396±0.00 3.574±0.00 2.504±0.89 1.415±0.23 10.831±0.00
ENST00000542523 N/A 1.131±0.00 N/A 1.698±0.44 1.112±0.15 1.767±0.00 1.200±0.00 0.943±0.32 0.970±0.63 N/A 0.483±0.00 2.413±0.54 2.669±0.00 1.822±0.00
ENST00000578697 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 7.539±0.00 N/A
ENST00000580203 N/A N/A N/A N/A N/A N/A N/A N/A 0.271±0.00 N/A N/A N/A N/A N/A
ENST00000580705 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 8.629±0.00 N/A N/A N/A
ENST00000581041 N/A N/A 2.581±0.00 3.920±0.00 N/A N/A N/A N/A 3.654±0.00 N/A 1.469±0.00 N/A 2.340±0.00 13.001±0.00
ENST00000581286 N/A N/A 21.780±0.00 N/A N/A N/A N/A 5.032±0.00 N/A N/A N/A N/A N/A N/A
ENST00000582809 N/A 0.848±0.00 N/A 0.863±0.00 N/A N/A 0.635±0.00 0.446±0.00 0.322±0.00 N/A N/A N/A 0.608±0.00 5.817±1.84
ENST00000619310 0.755±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00056B CIL_00056B_0002 CGP 17:62423867-62615481
CIL_000563 CIL_000563_0002 CGP 17:62458658-62693597

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001672 IDA regulation of chromatin assembly or disassembly
GO:0004672 IEA protein kinase activity
GO:0004674 IEA:IDA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IDA:IEA ATP binding
GO:0005634 IEA:IDA nucleus
GO:0005730 IDA nucleolus
GO:0005882 IDA intermediate filament
GO:0006468 IEA:IDA protein phosphorylation
GO:0006974 IDA cellular response to DNA damage stimulus
GO:0007049 IEA cell cycle
GO:0007059 IMP chromosome segregation
GO:0010507 NAS negative regulation of autophagy
GO:0016568 IEA chromatin modification
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0032435 IMP negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0035556 IDA intracellular signal transduction
GO:0048471 IDA perinuclear region of cytoplasm
GO:0071480 IDA cellular response to gamma radiation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000010779 tlk2 tousled-like kinase 2 protein_coding Danio_rerio
ENSMUSG00000020694 Tlk2 tousled-like kinase 2 (Arabidopsis) protein_coding Mus_musculus

Loading