C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: p21 protein (Cdc42/Rac)-activated kinase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000149269 PAK1 9606 - 11:77321707-77474635 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000278568 PAK1-002 77322948-77474060 protein_coding
  ENST00000356341 PAK1-001 77321707-77474062 protein_coding
  ENST00000524847 PAK1-007 77379383-77473735 protein_coding
  ENST00000525542 PAK1-005 77323269-77358953 processed_transcript
  ENST00000526103 PAK1-016 77353131-77355951 retained_intron
  ENST00000526910 PAK1-012 77379195-77392383 retained_intron
  ENST00000526968 PAK1-006 77392443-77474635 protein_coding
  ENST00000527457 PAK1-014 77323211-77379351 nonsense_mediated_decay
  ENST00000527535 PAK1-019 77332858-77347072 nonsense_mediated_decay
  ENST00000528203 PAK1-004 77323024-77411904 protein_coding
  ENST00000528592 PAK1-011 77379917-77411933 protein_coding
  ENST00000528633 PAK1-010 77392331-77411933 protein_coding
  ENST00000529248 PAK1-009 77379360-77411944 protein_coding
  ENST00000530358 PAK1-015 77349248-77356298 retained_intron
  ENST00000530617 PAK1-003 77322017-77412064 protein_coding
  ENST00000532711 PAK1-020 77336254-77343979 retained_intron
  ENST00000532991 PAK1-017 77336116-77349546 retained_intron
  ENST00000533285 PAK1-018 77329150-77349287 protein_coding
  ENST00000533468 PAK1-013 77355705-77379447 retained_intron
  ENST00000533568 PAK1-008 77358841-77473495 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000356341ENST00000525542ENST00000526103ENST00000527457ENST00000528203ENST00000530617
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000356341 N/A N/A N/A N/A 0.691±0.00 3.696±0.00 N/A N/A N/A 0.383±0.00 2.979±0.00 6.069±2.46 1.964±0.00 4.435±0.00
ENST00000525542 N/A 4.568±0.00 N/A N/A N/A N/A N/A 10.964±0.00 N/A N/A N/A N/A N/A N/A
ENST00000526103 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 13.629±0.00 N/A N/A
ENST00000527457 N/A N/A N/A N/A 4.394±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000528203 1.207±0.00 N/A N/A N/A 1.576±0.00 N/A N/A N/A 0.578±0.00 2.921±0.00 N/A 12.602±9.98 3.820±1.62 9.046±4.24
ENST00000530617 2.500±0.00 3.019±0.00 0.965±0.00 53.574±0.00 3.163±2.05 5.771±4.66 3.293±0.00 6.993±0.00 2.037±1.03 3.333±2.32 2.417±0.00 6.563±4.68 3.428±0.22 7.979±2.73

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001666 IEA response to hypoxia
GO:0001726 IDA ruffle
GO:0001934 IMP positive regulation of protein phosphorylation
GO:0004672 IDA:IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005518 IPI collagen binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0005911 IDA cell-cell junction
GO:0006468 IDA:IEA protein phosphorylation
GO:0006887 IEA exocytosis
GO:0006915 IEA apoptotic process
GO:0007015 IEA actin filament organization
GO:0007411 TAS axon guidance
GO:0007528 IEA neuromuscular junction development
GO:0010033 IEA response to organic substance
GO:0014704 ISS intercalated disc
GO:0016020 IEA membrane
GO:0016358 IEA dendrite development
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0019901 IEA protein kinase binding
GO:0030018 ISS Z disc
GO:0030424 ISS axon
GO:0030425 ISS dendrite
GO:0030426 IEA growth cone
GO:0031295 TAS T cell costimulation
GO:0031532 IMP actin cytoskeleton reorganization
GO:0031941 NAS filamentous actin
GO:0031965 ISS nuclear membrane
GO:0032869 IEA cellular response to insulin stimulus
GO:0032956 IEA regulation of actin cytoskeleton organization
GO:0033138 IDA positive regulation of peptidyl-serine phosphorylation
GO:0033148 IDA positive regulation of intracellular estrogen receptor signaling pathway
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038096 TAS Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042060 IMP wound healing
GO:0043113 IEA receptor clustering
GO:0043234 IDA protein complex
GO:0043507 IMP positive regulation of JUN kinase activity
GO:0045087 TAS innate immune response
GO:0046777 IDA protein autophosphorylation
GO:0048754 IMP branching morphogenesis of an epithelial tube
GO:0048812 ISS neuron projection morphogenesis
GO:0050852 TAS T cell receptor signaling pathway
GO:0051496 IMP positive regulation of stress fiber assembly
GO:0060244 IMP negative regulation of cell proliferation involved in contact inhibition

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000042624 pak1 p21/Cdc42/Rac1-activated kinase 1 protein_coding Danio_rerio
ENSDARG00000074186 pak1 p21/Cdc42/Rac1-activated kinase 1 protein_coding Danio_rerio
ENSMUSG00000030774 Pak1 p21 protein (Cdc42/Rac)-activated kinase 1 protein_coding Mus_musculus

Loading