C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: p21 protein (Cdc42/Rac)-activated kinase 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000356341 PAK1-001 ENSG00000149269 9606 - 11:77321707-77474062 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BreastColonLungMuscleOvaryPlacentaTestisENST00000356341
Transcript ID Breast Colon Lung Muscle Ovary Placenta Testis
ENST00000356341 0.691±0.00 3.696±0.00 0.383±0.00 2.979±0.00 6.069±2.46 1.964±0.00 4.435±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001726 IDA ruffle
GO:0001934 IMP positive regulation of protein phosphorylation
GO:0004672 IDA:IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005518 IPI collagen binding
GO:0005524 IEA ATP binding
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0005911 IDA cell-cell junction
GO:0006468 IDA:IEA protein phosphorylation
GO:0006887 IEA exocytosis
GO:0006915 IEA apoptotic process
GO:0007015 IEA actin filament organization
GO:0007411 TAS axon guidance
GO:0014704 ISS intercalated disc
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0030018 ISS Z disc
GO:0030424 ISS axon
GO:0030425 ISS dendrite
GO:0031295 TAS T cell costimulation
GO:0031532 IMP actin cytoskeleton reorganization
GO:0031941 NAS filamentous actin
GO:0031965 ISS nuclear membrane
GO:0033138 IDA positive regulation of peptidyl-serine phosphorylation
GO:0033148 IDA positive regulation of intracellular estrogen receptor signaling pathway
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038096 TAS Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042060 IMP wound healing
GO:0043234 IDA protein complex
GO:0043507 IMP positive regulation of JUN kinase activity
GO:0045087 TAS innate immune response
GO:0046777 IDA protein autophosphorylation
GO:0048754 IMP branching morphogenesis of an epithelial tube
GO:0048812 ISS neuron projection morphogenesis
GO:0050852 TAS T cell receptor signaling pathway
GO:0051496 IMP positive regulation of stress fiber assembly
GO:0060244 IMP negative regulation of cell proliferation involved in contact inhibition

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000033040 Pak1-001 protein_coding Mus_musculus 0 3001
ENSMUST00000156637 Pak1-002 nonsense_mediated_decay Mus_musculus 0 1803
ENSDART00000009560 pak1-201 protein_coding Danio_rerio 0 730
ENSDART00000101725 pak1-202 protein_coding Danio_rerio 0 673
ENSDART00000146147 pak1-001 protein_coding Danio_rerio 0 669
ENSDART00000123730 pak2b-002 protein_coding Danio_rerio 7e-35 154
ENSDART00000046678 pak2b-001 protein_coding Danio_rerio 7e-35 154
ENSDART00000126924 pak2b-201 protein_coding Danio_rerio 9e-24 117

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