C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: p21 protein (Cdc42/Rac)-activated kinase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000030774 Pak1 10090 + 7:97842935-97912381 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000033040 Pak1-001 97842935-97912381 protein_coding
  ENSMUST00000156637 Pak1-002 97842935-97912381 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000033040ENSMUST00000156637
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000033040 2.634±1.96 1.548±0.69 5.376±0.15 49.916±12.54 4.389±0.89 3.798±1.39 0.272±0.07 5.748±3.60 2.253±1.99 2.680±0.35 7.625±0.86 2.187±0.99 2.295±1.34 1.062±0.45
ENSMUST00000156637 N/A 1.780±0.40 N/A N/A 2.389±0.36 2.798±0.27 0.134±0.05 2.181±0.77 0.178±0.06 1.574±0.52 N/A 1.489±0.74 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002Q0 CIL_0002Q0_0003 CGP 7:97842935-98049663

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001666 IEA response to hypoxia
GO:0001726 IEA ruffle
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0004672 IDA protein kinase activity
GO:0004674 ISS protein serine/threonine kinase activity
GO:0005515 IEA protein binding
GO:0005518 IEA collagen binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 IEA cytosol
GO:0005886 IEA plasma membrane
GO:0005911 IEA cell-cell junction
GO:0005925 TAS focal adhesion
GO:0006468 ISS protein phosphorylation
GO:0007528 IGI neuromuscular junction development
GO:0010033 IEA response to organic substance
GO:0014704 IEA intercalated disc
GO:0016020 IEA membrane
GO:0016358 IDA dendrite development
GO:0019901 IEA protein kinase binding
GO:0030018 IEA Z disc
GO:0030424 IDA axon
GO:0030425 IEA dendrite
GO:0030426 IDA growth cone
GO:0031532 IEA actin cytoskeleton reorganization
GO:0031965 IEA nuclear membrane
GO:0032869 IEA cellular response to insulin stimulus
GO:0032956 IEA regulation of actin cytoskeleton organization
GO:0033138 IEA positive regulation of peptidyl-serine phosphorylation
GO:0033148 IEA positive regulation of intracellular estrogen receptor signaling pathway
GO:0042060 IEA wound healing
GO:0043113 IGI receptor clustering
GO:0043234 IEA protein complex
GO:0043507 IEA positive regulation of JUN kinase activity
GO:0046777 IEA protein autophosphorylation
GO:0048754 IEA branching morphogenesis of an epithelial tube
GO:0048812 IEA neuron projection morphogenesis
GO:0051496 IEA positive regulation of stress fiber assembly
GO:0060244 IEA negative regulation of cell proliferation involved in contact inhibition

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000042624 pak1 p21/Cdc42/Rac1-activated kinase 1 protein_coding Danio_rerio
ENSDARG00000074186 pak1 p21/Cdc42/Rac1-activated kinase 1 protein_coding Danio_rerio
ENSG00000149269 PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 protein_coding Homo_sapiens

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