C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: dopamine receptor D2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000346454 DRD2-003 ENSG00000149295 9606 - 11:113409615-113475120 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainColonLungPlacentaENST00000346454
Transcript ID Adipose Adrenal Brain Colon Lung Placenta
ENST00000346454 0.069±0.00 0.021±0.00 0.229±0.00 0.063±0.00 0.078±0.03 0.209±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002BX CIL_0002BX_0002 CGP 11:113387791-113475691

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001591 IDA dopamine neurotransmitter receptor activity, coupled via Gi/Go
GO:0001659 ISS temperature homeostasis
GO:0001975 ISS response to amphetamine
GO:0001976 ISS neurological system process involved in regulation of systemic arterial blood pressure
GO:0002027 ISS regulation of heart rate
GO:0002028 ISS regulation of sodium ion transport
GO:0002052 ISS positive regulation of neuroblast proliferation
GO:0004930 IEA G-protein coupled receptor activity
GO:0005515 IPI protein binding
GO:0005886 TAS plasma membrane
GO:0005887 IEA:IC integral component of plasma membrane
GO:0006874 IC cellular calcium ion homeostasis
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0007194 IDA negative regulation of adenylate cyclase activity
GO:0007195 IDA adenylate cyclase-inhibiting dopamine receptor signaling pathway
GO:0007270 ISS neuron-neuron synaptic transmission
GO:0007409 ISS axonogenesis
GO:0007416 ISS synapse assembly
GO:0007608 ISS sensory perception of smell
GO:0007626 ISS locomotory behavior
GO:0007628 ISS adult walking behavior
GO:0008104 ISS protein localization
GO:0008144 IDA drug binding
GO:0008285 ISS negative regulation of cell proliferation
GO:0008306 ISS associative learning
GO:0008542 ISS visual learning
GO:0009416 ISS response to light stimulus
GO:0015459 NAS potassium channel regulator activity
GO:0016021 IEA integral component of membrane
GO:0021853 ISS cerebral cortex GABAergic interneuron migration
GO:0021984 ISS adenohypophysis development
GO:0030336 ISS negative regulation of cell migration
GO:0030424 ISS axon
GO:0030425 ISS dendrite
GO:0030432 ISS peristalsis
GO:0030814 IDA regulation of cAMP metabolic process
GO:0032228 ISS regulation of synaptic transmission, GABAergic
GO:0032467 IMP positive regulation of cytokinesis
GO:0032922 ISS circadian regulation of gene expression
GO:0034776 IDA response to histamine
GO:0035556 IDA intracellular signal transduction
GO:0042220 ISS response to cocaine
GO:0042417 IC dopamine metabolic process
GO:0042493 ISS response to drug
GO:0042802 IPI identical protein binding
GO:0043266 ISS regulation of potassium ion transport
GO:0043278 ISS response to morphine
GO:0045776 ISS negative regulation of blood pressure
GO:0046488 ISS phosphatidylinositol metabolic process
GO:0048148 ISS behavioral response to cocaine
GO:0048149 ISS behavioral response to ethanol
GO:0048169 ISS regulation of long-term neuronal synaptic plasticity
GO:0048755 ISS branching morphogenesis of a nerve
GO:0050482 IDA arachidonic acid secretion
GO:0050709 IDA negative regulation of protein secretion
GO:0051209 ISS release of sequestered calcium ion into cytosol
GO:0051482 IDA positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0051584 IC regulation of dopamine uptake involved in synaptic transmission
GO:0051586 ISS positive regulation of dopamine uptake involved in synaptic transmission
GO:0051898 ISS negative regulation of protein kinase B signaling
GO:0051967 ISS negative regulation of synaptic transmission, glutamatergic
GO:0060124 ISS positive regulation of growth hormone secretion
GO:0060134 ISS prepulse inhibition
GO:0060158 IGI phospholipase C-activating dopamine receptor signaling pathway
GO:0060160 ISS negative regulation of dopamine receptor signaling pathway
GO:1901386 IDA negative regulation of voltage-gated calcium channel activity

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000075764 Drd2-201 protein_coding Mus_musculus 0 1024

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