C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000149357 LAMTOR1 9606 - 11:72085895-72103387 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000278671 LAMTOR1-001 72097292-72103387 protein_coding
  ENST00000535107 LAMTOR1-008 72094438-72103237 protein_coding
  ENST00000535872 LAMTOR1-002 72097427-72103297 nonsense_mediated_decay
  ENST00000538404 LAMTOR1-004 72097348-72103236 protein_coding
  ENST00000539797 LAMTOR1-007 72097820-72100725 processed_transcript
  ENST00000541403 LAMTOR1-005 72098537-72103280 retained_intron
  ENST00000544594 LAMTOR1-003 72097292-72099258 protein_coding
  ENST00000545249 LAMTOR1-006 72085895-72103246 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000278671ENST00000535872ENST00000538404ENST00000539797ENST00000544594ENST00000545249
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000278671 57.264±0.00 62.196±0.00 2.704±0.00 19.451±14.92 31.178±28.20 18.312±13.66 12.783±9.51 26.007±23.70 11.486±8.71 21.829±0.00 12.291±1.97 41.142±30.49 59.909±28.38 22.560±17.39
ENST00000535872 N/A 26.078±0.00 N/A 19.647±0.00 18.666±0.00 18.755±0.00 24.247±0.00 62.404±0.00 33.465±0.00 16.864±15.88 27.870±0.00 9.132±0.00 14.120±0.00 8.667±2.71
ENST00000538404 N/A N/A 1.454±0.00 N/A 0.763±0.00 N/A N/A N/A 1.172±0.00 0.818±0.00 N/A N/A N/A N/A
ENST00000539797 N/A N/A 4.256±0.00 6.048±0.00 1.741±0.00 2.752±0.00 1.506±0.00 N/A 4.909±0.00 1.915±0.00 N/A N/A N/A N/A
ENST00000544594 N/A N/A N/A 1.608±0.00 N/A N/A N/A 6.230±0.00 N/A 1.296±0.00 N/A N/A N/A N/A
ENST00000545249 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.808±0.00 N/A N/A N/A 5.443±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008XL CIL_0008XL_0001 VISTA 11:72069476-72670457
CIL_0002MI CIL_0002MI_0001 CGP 11:72080331-72110782

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001919 ISS regulation of receptor recycling
GO:0005085 IDA guanyl-nucleotide exchange factor activity
GO:0005515 IPI protein binding
GO:0005764 IDA lysosome
GO:0005794 IDA Golgi apparatus
GO:0005886 IDA plasma membrane
GO:0007032 ISS endosome organization
GO:0007040 ISS lysosome organization
GO:0010872 IMP regulation of cholesterol esterification
GO:0010874 IMP regulation of cholesterol efflux
GO:0016049 IMP cell growth
GO:0031902 ISS late endosome membrane
GO:0032008 IMP positive regulation of TOR signaling
GO:0032418 ISS lysosome localization
GO:0032439 ISS endosome localization
GO:0032947 IDA protein complex scaffold
GO:0034613 IMP cellular protein localization
GO:0042632 IMP cholesterol homeostasis
GO:0043231 IDA intracellular membrane-bounded organelle
GO:0043410 ISS positive regulation of MAPK cascade
GO:0043547 IDA positive regulation of GTPase activity
GO:0045121 ISS membrane raft
GO:0060620 IMP regulation of cholesterol import
GO:0070062 IDA extracellular vesicular exosome
GO:0071230 IMP cellular response to amino acid stimulus
GO:0071986 IDA Ragulator complex

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000076464 lamtor1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 protein_coding Danio_rerio
ENSMUSG00000030842 Lamtor1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 protein_coding Mus_musculus

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