C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: fer (fps/fes related) tyrosine kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000151422 FER 9606 + 5:108747822-109196841 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000281092 FER-001 108747822-109196841 protein_coding
  ENST00000438717 FER-201 108798114-109187672 protein_coding
  ENST00000502752 FER-004 108748967-108843001 processed_transcript
  ENST00000504143 FER-008 108748962-109188275 nonsense_mediated_decay
  ENST00000505323 FER-006 108924608-109044826 processed_transcript
  ENST00000509035 FER-005 108747841-108832924 processed_transcript
  ENST00000513676 FER-003 108748399-108832820 processed_transcript
  ENST00000513777 FER-007 109177517-109187667 processed_transcript
  ENST00000618353 FER-202 108924606-109187578 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryTestisENST00000281092ENST00000438717ENST00000502752
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Testis
ENST00000281092 N/A N/A N/A 1.406±0.00 N/A N/A 0.180±0.01 0.214±0.00 1.221±0.00 0.961±0.00 0.160±0.00 0.090±0.00 0.470±0.00
ENST00000438717 1.274±0.00 0.574±0.00 N/A 5.570±0.00 4.737±0.00 3.324±0.00 1.558±0.00 N/A N/A 3.462±1.96 N/A N/A 2.355±0.00
ENST00000502752 N/A 0.966±0.00 1.309±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 1.492±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00075K CIL_00075K_0001 CGP 5:108747822-109409994

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000226 IMP microtubule cytoskeleton organization
GO:0000278 IMP mitotic cell cycle
GO:0000790 IDA nuclear chromatin
GO:0001932 ISS regulation of protein phosphorylation
GO:0003779 IEA actin binding
GO:0004672 IEA protein kinase activity
GO:0004713 TAS:IEA protein tyrosine kinase activity
GO:0004715 IDA non-membrane spanning protein tyrosine kinase activity
GO:0005154 IDA epidermal growth factor receptor binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006468 TAS:IEA protein phosphorylation
GO:0006935 IEA chemotaxis
GO:0007155 IEA cell adhesion
GO:0007165 IEA signal transduction
GO:0008092 IEA cytoskeletal protein binding
GO:0008157 IEA protein phosphatase 1 binding
GO:0008283 IMP cell proliferation
GO:0008284 TAS positive regulation of cell proliferation
GO:0008289 IDA lipid binding
GO:0010591 IDA regulation of lamellipodium assembly
GO:0010762 IEA regulation of fibroblast migration
GO:0015629 IDA actin cytoskeleton
GO:0015630 IDA microtubule cytoskeleton
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0017137 IEA Rab GTPase binding
GO:0018108 IDA:IEA peptidyl-tyrosine phosphorylation
GO:0019221 IMP cytokine-mediated signaling pathway
GO:0019901 IEA protein kinase binding
GO:0030027 IDA lamellipodium
GO:0030054 IDA cell junction
GO:0030335 IMP positive regulation of cell migration
GO:0030838 IMP positive regulation of actin filament polymerization
GO:0031234 IDA extrinsic component of cytoplasmic side of plasma membrane
GO:0031532 ISS actin cytoskeleton reorganization
GO:0032496 ISS response to lipopolysaccharide
GO:0032869 ISS cellular response to insulin stimulus
GO:0033007 ISS negative regulation of mast cell activation involved in immune response
GO:0034446 ISS substrate adhesion-dependent cell spreading
GO:0034614 ISS cellular response to reactive oxygen species
GO:0035426 ISS extracellular matrix-cell signaling
GO:0035556 TAS intracellular signal transduction
GO:0036006 IMP cellular response to macrophage colony-stimulating factor stimulus
GO:0036119 ISS response to platelet-derived growth factor
GO:0038028 ISS insulin receptor signaling pathway via phosphatidylinositol 3-kinase
GO:0038095 ISS Fc-epsilon receptor signaling pathway
GO:0038109 ISS Kit signaling pathway
GO:0042058 IMP regulation of epidermal growth factor receptor signaling pathway
GO:0042503 IDA tyrosine phosphorylation of Stat3 protein
GO:0044331 ISS cell-cell adhesion mediated by cadherin
GO:0045295 IEA gamma-catenin binding
GO:0045296 IEA cadherin binding
GO:0046777 IDA protein autophosphorylation
GO:0048008 ISS platelet-derived growth factor receptor signaling pathway
GO:0050839 IEA cell adhesion molecule binding
GO:0050904 ISS diapedesis
GO:0051092 IMP positive regulation of NF-kappaB transcription factor activity
GO:0070102 IMP interleukin-6-mediated signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000012196 fer fer (fps/fes related) tyrosine kinase protein_coding Danio_rerio
ENSMUSG00000000127 Fer fer (fms/fps related) protein kinase protein_coding Mus_musculus

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