C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: fer (fps/fes related) tyrosine kinase
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000281092 FER-001 ENSG00000151422 9606 + 5:108747822-109196841 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainHeartKidneyLiverLungMuscleOvaryTestisENST00000281092
Transcript ID Brain Heart Kidney Liver Lung Muscle Ovary Testis
ENST00000281092 1.406±0.00 0.180±0.01 0.214±0.00 1.221±0.00 0.961±0.00 0.160±0.00 0.090±0.00 0.470±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00075K CIL_00075K_0001 CGP 5:108747822-109409994

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000226 IMP microtubule cytoskeleton organization
GO:0000278 IMP mitotic cell cycle
GO:0000790 IDA nuclear chromatin
GO:0001932 ISS regulation of protein phosphorylation
GO:0003779 IEA actin binding
GO:0004672 IEA protein kinase activity
GO:0004713 TAS:IEA protein tyrosine kinase activity
GO:0004715 IDA non-membrane spanning protein tyrosine kinase activity
GO:0005154 IDA epidermal growth factor receptor binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006468 TAS:IEA protein phosphorylation
GO:0006935 IEA chemotaxis
GO:0007155 IEA cell adhesion
GO:0007165 IEA signal transduction
GO:0008092 IEA cytoskeletal protein binding
GO:0008157 IEA protein phosphatase 1 binding
GO:0008283 IMP cell proliferation
GO:0008284 TAS positive regulation of cell proliferation
GO:0008289 IDA lipid binding
GO:0010591 IDA regulation of lamellipodium assembly
GO:0010762 IEA regulation of fibroblast migration
GO:0015629 IDA actin cytoskeleton
GO:0015630 IDA microtubule cytoskeleton
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0017137 IEA Rab GTPase binding
GO:0018108 IDA:IEA peptidyl-tyrosine phosphorylation
GO:0019221 IMP cytokine-mediated signaling pathway
GO:0019901 IEA protein kinase binding
GO:0030027 IDA lamellipodium
GO:0030054 IDA cell junction
GO:0030335 IMP positive regulation of cell migration
GO:0030838 IMP positive regulation of actin filament polymerization
GO:0031234 IDA extrinsic component of cytoplasmic side of plasma membrane
GO:0031532 ISS actin cytoskeleton reorganization
GO:0032496 ISS response to lipopolysaccharide
GO:0032869 ISS cellular response to insulin stimulus
GO:0033007 ISS negative regulation of mast cell activation involved in immune response
GO:0034446 ISS substrate adhesion-dependent cell spreading
GO:0034614 ISS cellular response to reactive oxygen species
GO:0035426 ISS extracellular matrix-cell signaling
GO:0035556 TAS intracellular signal transduction
GO:0036006 IMP cellular response to macrophage colony-stimulating factor stimulus
GO:0036119 ISS response to platelet-derived growth factor
GO:0038028 ISS insulin receptor signaling pathway via phosphatidylinositol 3-kinase
GO:0038095 ISS Fc-epsilon receptor signaling pathway
GO:0038109 ISS Kit signaling pathway
GO:0042058 IMP regulation of epidermal growth factor receptor signaling pathway
GO:0042503 IDA tyrosine phosphorylation of Stat3 protein
GO:0044331 ISS cell-cell adhesion mediated by cadherin
GO:0045295 IEA gamma-catenin binding
GO:0045296 IEA cadherin binding
GO:0046777 IDA protein autophosphorylation
GO:0048008 ISS platelet-derived growth factor receptor signaling pathway
GO:0050839 IEA cell adhesion molecule binding
GO:0050904 ISS diapedesis
GO:0051092 IMP positive regulation of NF-kappaB transcription factor activity
GO:0070102 IMP interleukin-6-mediated signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000000129 Fer-201 protein_coding Mus_musculus 0 3092
ENSMUST00000038080 Fer-202 protein_coding Mus_musculus 0 1465
ENSMUST00000151430 Thoc2-010 nonsense_mediated_decay Mus_musculus 0 486
ENSMUST00000047037 Thoc2-001 protein_coding Mus_musculus 0 486
ENSMUST00000124458 Thoc2-008 protein_coding Mus_musculus 0 486
ENSMUST00000145586 Thoc2-016 protein_coding Mus_musculus 0 318

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