C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: dopamine receptor D3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000151577 DRD3 9606 - 3:114128652-114199407 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000295881 DRD3-201 114128710-114179052 protein_coding
  ENST00000383673 DRD3-202 114128710-114179052 protein_coding
  ENST00000460779 DRD3-001 114128652-114199407 protein_coding
  ENST00000467632 DRD3-002 114128710-114178698 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBrainTestisENST00000295881ENST00000383673ENST00000460779ENST00000467632
Transcript ID Adrenal Brain Testis
ENST00000295881 N/A 0.063±0.00 0.177±0.00
ENST00000383673 N/A N/A 0.062±0.00
ENST00000460779 0.037±0.00 N/A N/A
ENST00000467632 N/A N/A 0.091±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0001591 ISS dopamine neurotransmitter receptor activity, coupled via Gi/Go
GO:0001963 IEA synaptic transmission, dopaminergic
GO:0001975 IEA response to amphetamine
GO:0002016 IEA regulation of blood volume by renin-angiotensin
GO:0002031 IDA G-protein coupled receptor internalization
GO:0004930 IEA G-protein coupled receptor activity
GO:0004952 IEA dopamine neurotransmitter receptor activity
GO:0005515 IPI protein binding
GO:0005886 IDA plasma membrane
GO:0005887 IEA integral component of plasma membrane
GO:0006874 IDA cellular calcium ion homeostasis
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0007191 IDA adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007194 IDA negative regulation of adenylate cyclase activity
GO:0007195 IEA adenylate cyclase-inhibiting dopamine receptor signaling pathway
GO:0007212 IEA dopamine receptor signaling pathway
GO:0007611 NAS learning or memory
GO:0007612 NAS learning
GO:0007626 ISS locomotory behavior
GO:0008144 ISS drug binding
GO:0008284 IEA positive regulation of cell proliferation
GO:0008542 ISS visual learning
GO:0014059 ISS regulation of dopamine secretion
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0019216 IEA regulation of lipid metabolic process
GO:0019904 IEA protein domain specific binding
GO:0030139 IEA endocytic vesicle
GO:0030814 IDA regulation of cAMP metabolic process
GO:0031748 IEA D1 dopamine receptor binding
GO:0032416 IEA negative regulation of sodium:proton antiporter activity
GO:0032467 IMP positive regulation of cytokinesis
GO:0032922 ISS circadian regulation of gene expression
GO:0034776 IDA response to histamine
GO:0035176 NAS social behavior
GO:0035240 IEA dopamine binding
GO:0035483 IEA gastric emptying
GO:0035815 IEA positive regulation of renal sodium excretion
GO:0040012 IEA regulation of locomotion
GO:0040014 IEA regulation of multicellular organism growth
GO:0042220 IEP response to cocaine
GO:0042417 IC dopamine metabolic process
GO:0042493 ISS response to drug
GO:0042995 IEA cell projection
GO:0043278 ISS response to morphine
GO:0045177 IEA apical part of cell
GO:0045187 IEA regulation of circadian sleep/wake cycle, sleep
GO:0045471 IEA response to ethanol
GO:0045776 ISS negative regulation of blood pressure
GO:0045840 ISS positive regulation of mitosis
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0046717 ISS acid secretion
GO:0048148 ISS behavioral response to cocaine
GO:0048715 ISS negative regulation of oligodendrocyte differentiation
GO:0050482 IDA arachidonic acid secretion
GO:0050709 IDA negative regulation of protein secretion
GO:0050883 ISS musculoskeletal movement, spinal reflex action
GO:0051584 IC regulation of dopamine uptake involved in synaptic transmission
GO:0051898 ISS negative regulation of protein kinase B signaling
GO:0060134 IMP prepulse inhibition
GO:0060160 IEA negative regulation of dopamine receptor signaling pathway
GO:0060161 ISS positive regulation of dopamine receptor signaling pathway
GO:0090325 IEA regulation of locomotion involved in locomotory behavior

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000032131 drd3 dopamine receptor D3 protein_coding Danio_rerio
ENSMUSG00000022705 Drd3 dopamine receptor D3 protein_coding Mus_musculus

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